Strychnos spinosa and high blood pressure - Temasoa, Yvanna;Ranaivoarimanitra, Patrice;Rajaonarison, Jean-François
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The aim of the present study is to valorize the use in traditional medicine of Strychnos spinosa (Loganiaceae) as an antihypertensive plant. On isolated rat aorta pre-contacted with phenilephrine the crude extract of the plant causes endothelium-dependent vasorelaxation with a relaxation EC50 value equal to 0.900 ± 0.054 mg/ml. L-NAME inhibits the vasorelaxation effect induced by the extract of Strychnos spinosa with an increase in EC50 value of 2.254± 0.140mg/ml, this shows that the vasorelaxation effect involves a mechanism that involves NO. The inhibition of the effect by propranolol, with…mehr

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Produktbeschreibung
The aim of the present study is to valorize the use in traditional medicine of Strychnos spinosa (Loganiaceae) as an antihypertensive plant. On isolated rat aorta pre-contacted with phenilephrine the crude extract of the plant causes endothelium-dependent vasorelaxation with a relaxation EC50 value equal to 0.900 ± 0.054 mg/ml. L-NAME inhibits the vasorelaxation effect induced by the extract of Strychnos spinosa with an increase in EC50 value of 2.254± 0.140mg/ml, this shows that the vasorelaxation effect involves a mechanism that involves NO. The inhibition of the effect by propranolol, with an EC50 of 2.762±0.138mg/ml demonstrates that the vasorelaxant effect involves the participation of beta2 adrenergic receptors.
Autorenporträt
Yvanna TEMASOA nasceu em Toamasina. Apaixonada pela investigação, prosseguiu o curso de Ciências Naturais e o curso de Valorização da Biodiversidade Vegetal (VBV) na Faculdade de Ciências, Tecnologia e Ambiente (FSTE) da Universidade de Mahajanga (Madagáscar) para poder trabalhar com plantas medicinais.