Somatostatin

Mitarbeit: Patel, Y.C.; Epelbaum, J.; Rubinow, D.R.; Davis, C.L.; Post, R.M.

• Broschiertes Buch

Produktbeschreibung

One of the phylogenetically oldest hormones, somatostatin is
a regulatory peptide with remarkable characteristics. It is
a nonclassical neurotransmitter discovered less than 20
years ago both in the central nervous system and in the
gastroenteropancreatic system. It regulates the secretion of
both pituitary and digestive hormones, it ensures nutrient
homeostasis and it has therapeutic uses. This volume deals
withall these aspects.

Produktdetails

• Basic and Clinical Aspects of Neuroscience .4
• Verlag: Springer / Springer Berlin Heidelberg / Springer, Berlin
• Artikelnr. des Verlages: 978-3-540-54569-9
• 1992.
• Seitenzahl: 80
• Erscheinungstermin: 17. Juli 1992
• Englisch
• Abmessung: 277mm x 210mm x 5mm
• Gewicht: 300g
• ISBN-13: 9783540545699
• ISBN-10: 3540545697
• Artikelnr.: 29009910

Inhaltsangabe

General Aspects of the Biology and Function of Somatostatin.- Molecular Heterogeneity of Somatostatin.- Evolution of Somatostatin Genes and Gene Products.- Anatomical Distribution of Somatostatin Cells.- Somatostatin in the Blood and Other Body Fluids.- Actions of Somatostatin.- Molecular Model of Somatostatin Action.- Regulation of Somatostatin Secretion and Gene Expression.- Physiological Significance of Somatostatin.- Somatostatin in Disease.- References.- Somatostatin Receptors in the Central Nervous System.- Somatostatin Receptors.- Somatostatin Receptors in Pathology.- Conclusion.- References.- Somatostatin in Neuropsychiatric Disorders.- Neuropsychiatric Disease-Related Alterations.- Central Nervous System Effects of Somatostatin.- Somatostatin in Affective Disorder: Clinical Relevance.- Endocrine Correlates.- Role in Seizure Disorders and Effects of Psychopharmacological Agents..- Conclusions.- References.- The Physiological Role of Somatostatin in the Regulation of Nutrient Homeostasis.- Release of Somatostatin.- Mechanisms of Somatostatin Release.- Physiological Effects of Somatostatin.- Somatostatin and Nutrient Entry into the Circulation.- References.- Therapeutic Use of Somatostatin and Octreotide Acetate in Neuroendocrine Tumors.- Pharmacology of Octreotide Acetate.- The Effects of Somatostatin and Octreotide on the Pituitary.- The Effects of Somatostatin and Octreotide on Neuroendocrine Tumors of the Gut.- Unresolved Issues.- References.