Prasad Patrekar, Vishal Dalvi, Chandrakant Patil

Solubility enhancement of diacerin using cyclodextrin

Solubility and evalution of diacerein using cyclodextrin as hydrophillic carriers

• Broschiertes Buch

Produktbeschreibung

Cyclorins, hydrophilic carriers, are cyclic polysaccharides which have property of forming inclusion complex with various guest molecules with suitable polarity and dimensions. They have been used extensively for solubility enhancement of hydrophobic drug/water insoluble drugs. Diacerein is anthraquinone compound designed to treatment of osteoarthritis. The purpose of this research was to enhance the solubility and therefore dissolution of Diacerein by complexation with -cyclodextrin ( CD) and hydroxyl propyl -cyclodextrin (HP CD).This study represents the formulation of inclusion complex with CD and HP CD by kneading method and their characterization and evaluation of improvement in dissolution profile. Inclusion complex compared to pure drug and physical mixtures, remarkable enhancement in invitro drug release profile in PH 6.8 phosphate buffer was obtained in both inclusion complexes of CD and HP CD, especially with HP CD. Complexation of Diacerein with hydrophilic carriers like CD and HP CD offers a major enhancement in drug solubility.

Produktdetails

• Verlag: LAP Lambert Academic Publishing
• Aufl.
• Seitenzahl: 84
• Englisch
• Abmessung: 220mm
• ISBN-13: 9783848486458
• ISBN-10: 3848486458
• Artikelnr.: 35561167

Autorenporträt

Mr. Prasad Patrekar has successfully completed M. Pharm in Pharmaceutics.He has also completed post graduate degree in management studies. He is having a blend of experience in teaching and industry. He has also published several articles in reputed journals. Presently he is working as Principal at Adarsh Institute of Pharmacy.