Bhagya Manoj Sattigeri

Sodium Valproate

Investigational Aspects of its Psychopharmacological Actions

• Broschiertes Buch

Produktbeschreibung

Histological, electrophysiological and behavioral studies suggest a regulatory role of GABA on the DAergic neurons. Behavioral studies in animals have demonstrated that drugs which influence the activity of central GABAergic systems modulate the intensity of behaviors dependent on the functional status of nigrostriatal and mesolimbic DAergic systems. Sodium valproate, enhances theGABAergic neurotransmission by acting through different mechanisms. Our study demonstrates that at higher doses valproate also enhances the central 5HTergic neurotransmission by releasing 5HT. Histological studies demonstrate an anatomical connection between the central ascending serotonergic pathway and nigrostriatal dopaminergic pathway. Drugs known to influence the activity of central GABAergic systems have been reported to modulate the intensity of behaviors dependent on the functioning of the nigrostriatal DAergic systems and mesolimbic DAergic systems. Hence sodium valproate was investigated for its interaction and influence on DAergic and 5HTergic systems with the help of behavioral models in animals with the hope of its use in specific psychiatric disorders.

Produktdetails

• Verlag: LAP Lambert Academic Publishing
• Aufl.
• Seitenzahl: 104
• Englisch
• Abmessung: 220mm
• ISBN-13: 9783659152139
• ISBN-10: 3659152137
• Artikelnr.: 36035220

Autorenporträt

Dr Bhagya Manoj Sattigeri is MD in Pharmacology with seventeen years of service. She is the Professor of Pharmacology in Sumandeep Vidyapeeth s SBKSMIRC, Vadodara, India. She is research oriented and her interest areas are Psychopharmacology, Geriatric Pharmacology and Pharmaco-economics.She has publications in national and international journals.