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SOCS proteins are regulators of various signal
transduction cascades that are essential to normal
physiology. Important advances have been made in
understanding their mode of action. However,
unresolved issues include the involvement of SOCS in
the modulation of specific pathways and the
mechanisms controlling stability and regulation of
these proteins. The importance of this is
underscored by the contribution of inappropriately
regulated SOCS activity to several pathologies
including cancer and inflammatory diseases.
This work provides further insights in the role of
SOCS proteins in different signalling pathways such
as leptin signal transduction. The hormone leptin
emerged as a key player in body weight regulation
but it also has peripheral effects on diverse body
functions. In the second part of this book novel
roles for the SOCS box domain in the cross-
regulation of other SOCS proteins and in substrate
binding are reported.
This work should help to further understand the
mechanisms underlying SOCS actions. Undoubtedly,
knowledge of how SOCS proteins are regulated may
lead to development of potent therapeutic options in
the treatment of several disorders.
transduction cascades that are essential to normal
physiology. Important advances have been made in
understanding their mode of action. However,
unresolved issues include the involvement of SOCS in
the modulation of specific pathways and the
mechanisms controlling stability and regulation of
these proteins. The importance of this is
underscored by the contribution of inappropriately
regulated SOCS activity to several pathologies
including cancer and inflammatory diseases.
This work provides further insights in the role of
SOCS proteins in different signalling pathways such
as leptin signal transduction. The hormone leptin
emerged as a key player in body weight regulation
but it also has peripheral effects on diverse body
functions. In the second part of this book novel
roles for the SOCS box domain in the cross-
regulation of other SOCS proteins and in substrate
binding are reported.
This work should help to further understand the
mechanisms underlying SOCS actions. Undoubtedly,
knowledge of how SOCS proteins are regulated may
lead to development of potent therapeutic options in
the treatment of several disorders.