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De-a lungul timpului acest sindrom a purtat mai multe denumiri, cum ar fi: sindromul plurimetabolic, sindromul X, sindromul X plus, sindromul metabolic X, sindromul metabolic cardiovascular, sindromul de insulino-rezisten¿¿ ¿ dislipideme, etc. De¿i s-au realizat numeroase progrese în în¿elegerea sindromului metabolic, fiziopatologia nu este foarte bine elucidat¿. În timp, au fost dezb¿tute mai multe concepte ale acestui sindrom ¿i s-a încercat în¿elegerea leg¿turilor dintre componentele sale.