Silencing host and viral genes improves survivability - C, Bala Amarnath
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In recent years, shrimp farming has become a vital component of the global aquaculture industry. However, disease outbreaks are one of the primary factors that hinder the growth and sustainability of shrimp farming. One of the most virulent and contagious diseases that affects shrimp is the White Spot Syndrome Virus (WSSV) infection. WSSV infection causes a wide range of symptoms, such as lethargy, disorientation, and a decrease in feeding activity, ultimately leading to high mortality rates. In recent years, the strategy of silencing host and viral genes through RNA interference (RNAi) has…mehr

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In recent years, shrimp farming has become a vital component of the global aquaculture industry. However, disease outbreaks are one of the primary factors that hinder the growth and sustainability of shrimp farming. One of the most virulent and contagious diseases that affects shrimp is the White Spot Syndrome Virus (WSSV) infection. WSSV infection causes a wide range of symptoms, such as lethargy, disorientation, and a decrease in feeding activity, ultimately leading to high mortality rates. In recent years, the strategy of silencing host and viral genes through RNA interference (RNAi) has emerged as a promising approach to control WSSV infection in shrimp aquaculture. This combined strategy involves the use of RNAi to silence the host genes responsible for viral replication and the viral genes required for successful infection. Bala Amarnath C and his research team have conducted extensive studies on the effectiveness of this combined strategy in improving survivability in shrimp. Their research has revealed that the silencing of host and viral genes improves survivability in shrimp and reduces the severity of WSSV infection. The mechanism behind this strategy lies in gene regulation and immune response. Silencing of the host genes responsible for viral replication significantly reduces the replication of the virus, while silencing viral genes required for successful infection decreases the virulence of the virus. RNA interference also plays a significant role in antiviral defense. The small interfering RNA (siRNA) produced during RNAi targets and degrades the viral RNA, further reducing viral replication and infection. This combined strategy of silencing host and viral genes has proven to be effective in disease management and disease resistance in shrimp aquaculture. This strategy is also a more environmentally friendly approach to disease prevention than traditional chemical treatments. In conclusion, Bala Amarnath C and his team's research on the combined strategy of silencing host and viral genes through RNAi is a significant step towards sustainable shrimp farming. The strategy's effectiveness in improving survivability in shrimp and reducing the severity of WSSV infection makes it a promising approach for disease control and prevention in the shrimp aquaculture industry.