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This book is a medical scientific book that sheds the light on some translational points of view, to improve the clinical outcome of the practice of the ex-vivo perfusion lung transplantation. The book discusses some molecular bases of the ischemic reperfusion injury, to which the lung graft is exposed, and provides suitable and applicable recommendations to interfere with those molecular bases. In addition, the book provides a short concentrated clinical review of the bilateral lung transplantation surgery, the associated immunosuppression and the state of the art of the ex-vivo perfusion technique.