Serotonin-Dopamine Interaction: Experimental Evidence and Therapeutic Relevance

Volume 172
Herausgeber: Di Giovanni, Giuseppe; Esposito, Ennio; Di Matteo, Vincenzo

• Gebundenes Buch

Produktbeschreibung

This book provides a unique and timely multidisciplinary synthesis of our current knowledge of the anatomy, pharmacology, physiology and behavioral data of the serotonin (5-HT)-dopamine (DA) interactions. Central serotonergic and dopaminergic systems play a critical role in the regulation of normal and abnormal behaviors. Moreover, recent evidence suggests that the dysfunction of the DA and 5-HT neurotransmitter systems contribute to various mental disorders including depression, schizophrenia, drug addiction and Parkinson's disease. This extremely important topic is of wide interest within the scientific community, with relevance not only to specialists but also to general practitioners and students. The book provides a valuable contribution to the debate on new pharmacological approaches for several psychopathological states, with contributions from expert neuroscientists and pharmacologists who comprehensively survey the most significant currently active areas of dopamine/serotonin interactions.

Produktdetails

• Verlag: Elsevier Science
• Seitenzahl: 688
• Erscheinungstermin: 1. November 2008
• Englisch
• Abmessung: 259mm x 198mm x 33mm
• Gewicht: 1792g
• ISBN-13: 9780444532350
• ISBN-10: 0444532358
• Artikelnr.: 24764533

Inhaltsangabe

1. SEROTONIN-DOPAMINE INTERACTIONS IN THE CENTRAL NERVOUS SYSTEM
1. Serotonin-Dopamine Interaction: an overview.
2. Serotonin control of central dopaminergic function: focus on in vivo
microdialysis studies.
3. Serotonin-Dopamine Interaction: electrophysiological evidence.
4. Functional genetic polymorphisms in serotonin and dopamine gene systems
and their significance in behavioural disorders.
2. SEROTONIN-DOPAMINE INTERACTIONS IN SCHIZOPHRENIA
5. Distribution of 5-HT and DA receptors in primate prefrontal cortex:
implications for pathophysiology and treatment.
6. Alterations of dopamine and serotonin transmission in schizophrenia.
7. Serotonin and dopamine interactions in psychosis prevention.
8. Role of serotonin and dopamine receptor binding in antipsychotic
efficacy.
9. In vivo actions of atypical antipsychotic drug on serotonergic and
dopaminergic systems.
10. Neuropharmacology of second-generation antipsychotic drugs: a validity
of the serotonin-dopamine hypothesis.
11. Serotonin-dopamine interactions: implications for the design of novel
therapeutic agents for psychiatric disorders.
3. SEROTONIN-DOPAMINE INTERACTIONS IN DEPRESSION
12. The dorsal raphe nucleus and serotonin -implications for
neuroplasticity linked to major depression and Alzheimer's disease.
13. Dynamics of the dopaminergic system as a key component to the
understanding of depression.
14. Physiological and therapeutic relevance of constitutive activity of
5-HT2A and 5-HT2C receptors for the treatment of depression.
15. The role of dopamine and serotonin in suicidal behaviour and
aggression.
4. SEROTONIN-DOPAMINE INTERACTIONS IN DRUG ADDICTION
16. Prospects for serotonin 5-HT2R pharmacotherapy in psychostimulant
abuse.
17. Pharmacological inhibition of dopamine- and serotonin activity blocks
spontaneous and cocaine-activated behaviour.
18. Serotonin receptors as potential targets for modulation of nicotine use
and dependence.
19. Dopamine/Serotonin releasers as medications for stimulant addictions.
20. PTEN-5-HT2C coupling: A new target for treating drug addiction.
5. SEROTONIN-DOPAMINE INTERACTIONS IN MOTOR DISORDERS
21. Serotonin modulation of the basal ganglia circuitry: therapeutic
implication for Parkinson's disease and other motor disorders.
22. Serotonin-Dopamine interaction in the induction and maintenance of
LDOPA-induced dyskinesias.
23. Parkinson's disease - opportunities for novel therapeutics to reduce
the problems of levodopa therapy.
24. Neurobiological basis of serotonin-dopamine antagonists in the
treatment of Gilles de la Tourette syndrome.
6. SEROTONIN-DOPAMINE INTERACTIONS IN ATTENTIONAL PROCESSES, LEARNING AND
MEMORY
25. Serotonergic and dopaminergic modulation of attentional processes.
26. Dopamine-serotonin interactions in attention-deficit/hyperactivity
disorder (ADHD).
27. Serotonin/dopamine interaction in learning.
28. Serotonin-dopamine interaction in memory formation.
29. The roles of dopamine and serotonin, and of their receptors, in
regulating sleep and waking.