Packed with real-world examples, this book illustrates the 12 principles of green chemistry. These diverse case studies demonstrate to scientists and students that beyond the theory, the challenges of green chemistry in pharmaceutical discovery and development remain an ongoing endeavor. By informing and welcoming additional practitioners to this mission, the negative environmental impact of pharmaceutical products will continue to be minimized. Green chemistry is the methodology by which chemical production in this industry can become more efficient, adding environmental stewardship to the noble mission of treating human disease.…mehr
Packed with real-world examples, this book illustrates the 12 principles of green chemistry. These diverse case studies demonstrate to scientists and students that beyond the theory, the challenges of green chemistry in pharmaceutical discovery and development remain an ongoing endeavor. By informing and welcoming additional practitioners to this mission, the negative environmental impact of pharmaceutical products will continue to be minimized. Green chemistry is the methodology by which chemical production in this industry can become more efficient, adding environmental stewardship to the noble mission of treating human disease.
Stefan Koenig received his PhD from Yale University before conducting postdoctoral research at the ETH (Swiss Federal Institute) in Zurich, Switzerland. He embarked on his professional career in the pharmaceutical industry at Sepracor (now Sunovion Pharmaceuticals). Currently, he is a scientist at Genentech and chair of Roche/Genentech's global Green Chemistry Technical Working Group.
Inhaltsangabe
Preface Acknowledgments 1 Introduction to Green Pharmaceutical Science: Fact Fiction and Future 2 Green Chemistry in Drug Development 3 Development of Green-by-Design Practical Biocatalytic Processes 4 Application of Green Metrics to Scalable Industrial Synthesis Plans: Approaches to Oseltamivir Phosphate (Tamiflu R _) 5 The Road to Becoming Green: Process Development of AR-A2 an Active Pharmaceutical Ingredient with Antidepressant Activity 6 Improved and Greener Process for Pioglitazone and Its Pharmaceutically Acceptable Salts 7 The Development of a Convergent Green Synthesis of Linezolid an Oxazolidinone Antibacterial Agent 8 Development of a Nonaqueous Process for the Synthesis of 3-Amino-pentan-1 5-diol 9 Development of a Robust Environmentally Responsible Process for the Manufacture of Tofacitinib Citrate 10 Selective Nitration under cGMP Conditions 11 Going Green Using Combined Real-Time Analytics and Process Automation 12 Approaches to the Scale-Up of Organic Chemistry Using Microwave Heating 13 Challenges Faced and Future Directions Index
Preface Acknowledgments 1 Introduction to Green Pharmaceutical Science: Fact Fiction and Future 2 Green Chemistry in Drug Development 3 Development of Green-by-Design Practical Biocatalytic Processes 4 Application of Green Metrics to Scalable Industrial Synthesis Plans: Approaches to Oseltamivir Phosphate (Tamiflu R _) 5 The Road to Becoming Green: Process Development of AR-A2 an Active Pharmaceutical Ingredient with Antidepressant Activity 6 Improved and Greener Process for Pioglitazone and Its Pharmaceutically Acceptable Salts 7 The Development of a Convergent Green Synthesis of Linezolid an Oxazolidinone Antibacterial Agent 8 Development of a Nonaqueous Process for the Synthesis of 3-Amino-pentan-1 5-diol 9 Development of a Robust Environmentally Responsible Process for the Manufacture of Tofacitinib Citrate 10 Selective Nitration under cGMP Conditions 11 Going Green Using Combined Real-Time Analytics and Process Automation 12 Approaches to the Scale-Up of Organic Chemistry Using Microwave Heating 13 Challenges Faced and Future Directions Index
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