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The choice of root end filling material becomes one of the many factors relevant to the success of the endodontic surgery. The prognosis ultimately depends upon various factors like the correct bevel, adequate access, hemorrhage control, correct retrograde filling and preparation, quality of retrograde filling and individual host responses. This book is an attempt to comprehensively review and record the various retrograde filling materials of the past, present and future in an exhaustive yet succinct manner.