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Zinc and selenium are essential microelements in human body. Their main sources are eggs, fish, chicken, etc. They provide numerous health benefits, zinc has cellular function, antioxidant property, growth, aging and selenium is responsible for mood, thyroid function, cardiovascular disease prevention, and cancer prevention among various other functions. Higher concentration of oral zinc supplementation can inhibit acid production by bacterial plaque and have potential effect on the process of remineralization by releasing the production of calcium and phosphorus. Thus, inhibit the dental caries formation. Selenium is a naturally occurring component of human enamel and dentine that helps to reduce the duration and severity of oral mucositis. This book gives an overview on role of zinc and selenium on general as well as oral health.