Keder N. Prasad

Regulation of Differentiation in Mammalian Nerve Cells

• Broschiertes Buch

Produktbeschreibung

Several model systems have been used to understand the cellular and molecular mechanisms of differentiation of mammalian nerve cells. Each model system has unique advantages and disadvantages and is suited for the study of only certain aspects of differentiation. In this book, the techniques of these models and the usefulness and limita tion of each model system are discussed. An awareness of the use and misuse of each model system is important for a rational interpretation of data and for a reasonable comparison of data obtained from different model systems. With the use of clonal lines of neuronal cells and hybrid neural cells (neural cells x nonneural cells), many new concepts have emerged con cerning the regulation of differentiated functions, the relationship between the expressions of individual differentiated functions, and the relationship between differentiation and malignancy. Some of these concepts have already proved to be relevant to regulation of differentiation in vivo. These new emerging concepts are discussed extensively in this book. Many new agents (physiological and nonphysiological) which induce or increase the expression of one or more differentiated functions have been identified. These agents will be useful biological tools for further studies of the regulation of differentiation in mamma lian nerve cells. This book describes the role of each agent in d- vii viii PREFACE ferentiation of nerve cells by focusing on different model systems and provides a rational basis for selecting the particular differentiating agents for specific problems of differentiation processes.

Produktdetails

• Verlag: Springer / Springer US / Springer, Berlin
• Artikelnr. des Verlages: 978-1-4684-8114-3
• 1980
• Seitenzahl: 260
• Erscheinungstermin: 26. November 2012
• Englisch
• Abmessung: 229mm x 152mm x 15mm
• Gewicht: 385g
• ISBN-13: 9781468481143
• ISBN-10: 1468481142
• Artikelnr.: 40768499

Inhaltsangabe

1. Definition and Methodologies.- Definition of Differentiation.- Criteria of Differentiation of Nerve Cells.- Available Models with Which to Study the Problem of Differentiation.- Conclusion.- References.- 2. Neutral Induction.- Neural Induction.- Current Status of Induction Mechanisms of Neural Tissue.- References.- 3. Role of Cyclic Nucleotides in Regulation of Differentiation of Nerve Cells.- Experimental Models.- Methods of Evaluating Changes in Genetic and Structural Expressions.- Modification of Gene Expression and Morphology Unique to Cell Culture Condition and Experimental Models.- Regulation of Morphological Differentiation.- Polyunsaturated Fatty Acid Metabolism during Differentiation.- Modification of Gene Expression by cAMP.- Effect of Vitamin C.- Can Differentiated Cells Act As a Strong Antigen?.- Suggestion of a New Approach for the Treatment of Neuroblastomas.- Clinical Trial of Differentiating Agents.- Conclusion.- References.- 4. Role of Agents Other than cAMP in the Regulation of Differentiation of Nerve Cells.- Nerve Growth Factor.- Effect of Thyroid Hormone.- Effect of Growth Hormone.- Cell-Cycle Changes during Neuronal Differentiation.- Role of Cell Interactions in the Regulation of Cholinergic Enzymes during Neural Differentiation.- Regulation of Neural Tube Closure.- Effect of Nonneural Elements.- Effect of Heavy Water (D2O).- Effect of Serum-Free Medium and X Irradiation.- Effect of 6-Thioguanine, Cytosine Arabinoside, Methotrexate, and 5-Bromodeoxyuridine.- Effect of Glial Extract.- Effect of Hypertonic Medium.- Effect of Collagen.- Effect of Liposome.- Conclusion.- References.- 5. Parent and Hybrid Neuroblastoma Cells in Culture as a Model System for Neuronal Function.- Hybrid Cells (Mouse Neuroblastoma Cells × Mouse Fibroblast Cells).-Hybrid Cells (Mouse Neuroblastoma Cells × Rat Glioma Cells).- Hybrid Cells (Mouse Neuroblastoma Cells × Mouse Sympathetic Ganglion Cells).- Hybrid Cells in the Study of Narcotic Addiction.- Uptake Study Using Parent Neuroblastoma Clones.- Intracellular Biogenic Amines.- Transport of Glucose.- Metabolism of Glycogen.- Distribution of Free Nucleotides.- Distribution of Free Amino Acids.- Phospholipid Metabolism.- Immunology of Neuroblastoma Cells.- Effect of Quinazoline Antifolates.- Effect of Nonneural Cells on the Expression of Neuronal Functions.- Conclusion.- References.- 6. Some Aspects of Development of Nervous Tissue.- Morphogenesis.- Neuronal Interaction.- Cell Recognition.- Cell Adhesion.- Neuronal Death.- Functions of Cholinergic Input.- Neuronal Plasticity.- References.