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Herbal drugs are very much popular in worldwide today. In earlier time the Ayurvedic practitioners collected the herbal drugs themselves from forests, river sides or any places. But now due to huge use these crude drugs are available commercially. Traditional and herbal remedies are currently being encouraged, recommended and promoted by WHO in national health care systems due to their ease of availability at low cost as well as because they are safer and most people have their faith in these remedies.The liver, which is a versatile organ present in the vertebrates, is center to the metabolic disposition of virtually all endogenous and exogenous chemicals.The present investigation indicates that Ocimum Canum (AQ) and Ocimum Canum (PE) extract shows significant protection against thioacetamide-induced toxicity by its ability to ameliorate the lipid peroxidation through the free radicals scavenging activity.