Recent Advances in Parkinsons Disease

Part I: Basic Research Volume 183

• Gebundenes Buch

Produktbeschreibung

This first volume starts with an overview on current perspectives in genetic research and on the molecular mechanisms of neurodegeneration. This is followed by a selection of hot topics in pathophysiological research, from molecular studies to system-level investigations based on in vivo electrophysiological recordings and neurocomputational methods. Complete overview of hot topics and approaches to current PD research, from molecules, to brain circuits, to clinical and therapeutic applications. Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research. All chapters include comprehensive background information and are written in a clear form that is accessible also to the non-specialist.

Produktdetails

• Verlag: Elsevier Science
• Seitenzahl: 332
• Erscheinungstermin: 18. Oktober 2010
• Englisch
• Abmessung: 236mm x 193mm x 23mm
• Gewicht: 885g
• ISBN-13: 9780444536143
• ISBN-10: 0444536140
• Artikelnr.: 29930392

Inhaltsangabe

Section I: Genetic and molecular mechanisms of neurodegeneration in PD 1.
Identifying PD-causing genes and genetic susceptibility factors: current
approaches and future prospects 2. The impact of genetic research on our
understanding of Parkinson's Disease 3. Unraveling the role of defective
genes 4. What causes the death of dopaminergic neurons in Parkinson's
disease? 5. Intracellular Signaling Pathways In Dopamine Cell Death And
Axonal Degeneration 6. Control of mitochondrial integrity in Parkinson's
Disease 7. Role of Post-Translational Modifications in Modulating the
Structure, Function and Toxicity of a-synuclein: Implications for
Parkinson's Disease Pathogenesis and Therapies
Section II: Cellular and system-level pathophysiology of the basal ganglia
in P 8. The role of dopamine in modulating the structure and function of
striatal circuits 9. Assemblies of glutamate receptor subunits with
post-synaptic density proteins and their alterations in Parkinson's disease
10. Adenosine-dopamine interactions 11. Maladaptive plasticity in
L-DOPA-induced dyskinesia 12. Effects of GPi and STN inactivation on
physiological, motor, cognitive and motivational processes in animal models
of Parkinson's disease 13. Computational physiology of the basal ganglia in
Parkinson's disease 14. Neurocomputational models of motor and cognitive
deficits in Parkinson's Disease