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Seaweeds are multicellular macroalgae used as a potentially renewable resource in the field of medical and commercial environment. Also, it has strong modulating effects on oxidative stress-related diseases like cancers etc. The antioxidant properties of several kinds of algae have been investigated for their anti-inflammatory, antinociceptive, and anti-cancer effects. From the results, it was quite evident that the ethanolic extracts of enteromporpha sp (seaweed) have elevated antioxidant activity when compared to aqueous extract. The finding of the current report appears useful for further research aiming to isolate, identify and characterize the specific phenolic compounds in Enteromorpha for its industrial and pharmaceutical purposes. In the future, these marine algae-derived compounds will be used more often in pre-clinical studies for drug discovery.