Quinones are members of a class of aromatic compounds with two oxygen atoms bonded to the ring as carbonyl groups. This volume covers more clinical aspects of quinines, such as anticancer properties, as well as their role in nutrition and in age-related diseases.
Quinones are members of a class of aromatic compounds with two oxygen atoms bonded to the ring as carbonyl groups. This volume covers more clinical aspects of quinines, such as anticancer properties, as well as their role in nutrition and in age-related diseases.
Helmut Sies, MD, PhD (hon), studied medicine at the universities of Tübingen, Munich, and Paris. He was the professor and chair of the Institute for Biochemistry and Molecular Biology I at Heinrich-Heine-University Düsseldorf, Germany, where he is now professor emeritus. He is a member of the German National Academy of Sciences Leopoldina and was the president of the North Rhine-Westphalian Academy of Sciences and Arts. He was named 'Redox Pioneer'; was the president of the Society for Free Radical Research International (SFRRI). Helmut Sies introduced the concept of "Oxidative Stress? in 1985, and was the first to reveal hydrogen peroxide as a normal constituent of aerobic cell metabolism. His research interests comprise redox biology, oxidants, antioxidants, micronutrients.
Inhaltsangabe
Section I: Mitochondrial Ubiquinone and Reductases
1: Mitochondrial Quinone Reductases: Complex I
2: Q-Cycle Bypass Reactions at the Qo Site of the Cytochrome bc1 (and Related) Complexes
3: Targeting Coenzyme Q Derivatives to Mitochondria
4: The Mitochondrial Interplay of Ubiquinol and Nitric Oxide in Endotoxemia
5: Mitochondrial Respiratory Chain Dysfunction Caused by Coenzyme Q Deficiency
6: Coenzyme Q Cytoprotective Mechanisms
7: Dietary Coenzyme Q10 and Mitochondrial Status
Section II: Anticancer Quinones and Quinone Oxidoreductases
8: NAD(P)H:Quinone Oxidoreductase 1 (NQO1, DT-Diaphorase), Functions and Pharmacogenetics
9: Structure and Mechanism of NAD[P]H:Quinone Acceptor Oxidoreductases (NQO)
