Quantitative Determination of Immunosuppressant Drugs by LC-MS/MS

Quantitative Determination of Immunosuppressant Drugs by LC-MS/MS

Bioanalysis of Immunosuppressant Drugs

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Due to narrow therapeutic indices of immunosuppressants and highly variable pharmacokinetics, therapeutic drug monitoring is necessary to individualize immunosuppressant dosage following organ transplantation. Until recently, monitoring was performed primarily using immunoassays; however, there is an increasing shift to HPLC coupled with MS/MS, due to its greater sensitivity and specificity. Online sample clean-up with either a single analytical column or with 2D chromatography significantly reduces manual handling and is essential to minimize matrix effects and maximize specificity. Coupled w...