Quantitative Bioanalysis of Anticancer Drugs by LC-MS/MS

Quantitative Bioanalysis of Anticancer Drugs by LC-MS/MS

Analysis of Anticancer Drugs

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Monitoring of anticancer drugs in biological fluids and tissues is important during pre-clinical and clinical use. Traditionally, liquid chromatography (LC) in combination with ultraviolet, fluorescence, or electrochemical detection is employed for this purpose. The successful hyphenation of LC and mass spectrometry (MS), however, has dramatically changed scope of analysis. MS detection provides better sensitivity and selectivity than UV detection and, in addition, is applicable to a significantly larger group of compounds than fluorescence or electrochemical detection. As new drugs continuous...