Psychiatric Genetics - Leboyer, Marion / Bellivier, Frank (eds.)
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Enthusiasm about the role that genetics plays in our understanding of behavioral phenotypes has led to the development of many new epidemiological and statistical strategies, as well as to refinements in phenotype analysis. In Psychiatric Genetics: Methods and Reviews, hands-on experts comprehensively review the tools and methods currently available to uncover the genetic basis of psychiatric disorders, and then demonstrate through archetypical examples how these strategies can be used. Casting their net widely, the authors critically examine the key methodological issues involved in…mehr

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Produktbeschreibung
Enthusiasm about the role that genetics plays in our understanding of behavioral phenotypes has led to the development of many new epidemiological and statistical strategies, as well as to refinements in phenotype analysis. In Psychiatric Genetics: Methods and Reviews, hands-on experts comprehensively review the tools and methods currently available to uncover the genetic basis of psychiatric disorders, and then demonstrate through archetypical examples how these strategies can be used. Casting their net widely, the authors critically examine the key methodological issues involved in phenotypic analysis-including study design, molecular techniques, clinical interviews, and population sampling methods-and discuss new and alternate strategies that identify candidate symptoms and endophenotypes with better genetic validity. These strategies suggest cognitive intermediate phenotypes in schizophrenia, show how personality disorders may generate biologically mediated traits in the full-blown disorders, and yield data about P50 and P300 as endophenotypes in schizophrenia and alcoholism. One of the most promising approaches for the identification of valid phenotypes-the union of neuropsychological experimental designs and in vivo physiological brain mapping-is also discussed.
Practical and timely, Psychiatric Genetics: Methods and Reviews lays the cornerstone for the new diagnostics in psychiatric genetics-the unraveling of the genetic basis of psychiatric disorders and the development of new therapies through the precise identification of the phenotypes involved.
Rezensionen
"...a valiant attempt to make sense of a substantial portion of the methodological aspects of research in psychiatric genetics. Students and senior investigators should both give serious consideration to this book's arguments and advice." - Genes, Brain and Behavior

"...provides a relatively succinct introduction to a range of issues relating to the filed of psychiatric genetics...would be an excellent book for a young researcher about to enter the field of psychiatric genetics and would enable him or her to obtain a rapid overview of methodological issues." - Journal of Medical Genetics

"...great for getting new ideas as well as suggestions for how to deal with practical research questions." - Psychological Medicine

"This book is very useful for students or psychiatrists interested in genetics and how it applies to psychiatric illness. It is one of few in the field to give a comprehensive review of the field." -Doody's Health Sciences Book Review Journal

"Marion Leboyer and Frank Bellivier have put together a very good review of the variety of methods and approaches previously used in this complex area of research and, for this reason, this book provides a useful text for someone entering the field of psychiatric genetics." -Human Genetics