Natalya Kurochkina

Protein Structure and Modeling

• Gebundenes Buch

Produktbeschreibung

This book will consider principles of the organization of protein molecules, the relationships between primary, secondary, and tertiary structure, the determinants of protein conformation, and the applications of structure determination and structure modeling in biomedical research.

Produktdetails

• Verlag: Springer / Springer Nature Singapore / Springer, Berlin
• Artikelnr. des Verlages: 978-981-13-6600-0
• 1st ed. 2019
• Seitenzahl: 284
• Erscheinungstermin: 18. Juni 2019
• Englisch
• Abmessung: 241mm x 160mm x 20mm
• Gewicht: 608g
• ISBN-13: 9789811366000
• ISBN-10: 9811366004
• Artikelnr.: 54952060

Inhaltsangabe

CHAPTER 1 - Protein Structure

1.1 Polypeptide chain

1.2 Ligand binding

1.3 Active site

1.3 Structure-function

CHAPTER 2 - Conformational transitions

2.1 Types of transitions in molecular systems

2.2 Conformational states

2.3 Quantum motions

2.4 Myoglobin and hemoglobin

2.5 Cytochromes

2.6 Tobacco mosaic virus coat protein

2.7 Fibrin-fibrinogen

2.8 Conformational changes of side chains in protein interior as a basis of the conformational states of the molecule

CHAPTER 3 - Allosteric regulation

3.1 Proteins

3.2 Nucleic acids

3.3 Small ligands

CHAPTER 4 - Protein channels

4.1 Structure-function

4.2 Signaling

CHAPTER 5 - Helical assemblies

5.1 Determinants of specific helix recognition

5.2 Types of assemblies

CHAPTER 6 - multiprotein complexes

6.1 Postsynaptic density

6.2 Viruses

6.3 Implications in signaling

CHAPTER 7 - Methods of structure determination

7.1 X-Ray crystallography, NMR and Electron Microscopy

7.2 NMR

7.3 Electron Microscopy

CHAPTER 8 - Protein modeling

8.1 Helix and its interactions

8.2 Ligands

8.3 Dynamics

References

Dictionary