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This issue of PET Clinics focuses on Prostate Cancer Imaging and Therapy, and is edited by Drs. Cristina Nanni and Richard P. Baum. Articles will include: Clinicians Need for Imaging of Prostate Cancer; Imaging of Prostate Cancer using 11C-Choline; Imaging of Prostate Cancer using FACBC; Imaging of Prostate Cancer using Ga-Bombesin; Imaging of Prostate Cancer using 18F-Choline; Imaging of Prostate Cancer using Cu-64 Prostate-specific membrane antigen; From bench to bed: New Gastrin releasing peptide receptor-directed radioligands and their use in prostate cancer; Imaging of Prostate Cancer using Ga-68 Prostate-specific membrane antigen; Imaging of Prostate Cancer using F-18 Prostate-specific membrane antigen; Imaging of Prostate Cancer using uPAR-PET; PET/CT for radiation therapy planning of Prostate Cancer; and more!