Cells maintain uneven distribution of Na, K and Ca ions across the cell membrane and membranes of intracellular organellae. Cells exert their functions by allowing for some ion to cross the membrane through ion channels which either produces an electrical effect across the membrane or switches on a series of chemical or physicochemical reactions. This is a comprehensive book about these vitally important ion channels with detailed description of the molecular structure and function and especially of activators and inhibitors. All chapters are written by renowned specialists in their field.
Cells maintain uneven distribution of Na, K and Ca ions across the cell membrane and membranes of intracellular organellae. Cells exert their functions by allowing for some ion to cross the membrane through ion channels which either produces an electrical effect across the membrane or switches on a series of chemical or physicochemical reactions. This is a comprehensive book about these vitally important ion channels with detailed description of the molecular structure and function and especially of activators and inhibitors. All chapters are written by renowned specialists in their field.
Section I: Voltage-Dependent Ion Channels.- A. Voltage-Dependent Na Channels.- 1 Structure and Functions of Voltage-Dependent Na+ Channels.- 2 Sodium Channel Blockers and Activators.- B. Voltage-Dependent Ca-Channels.- 3 Classification and Function of Voltage-Gated Calcium Channels.- Structure of the Voltage-Dependent L-Type Calcium Channel.- 5 Ca2+ Channel Antagonists and Agonists.- C. Voltage-Dependent K-Channels.- 6 Overview of Potassium Channel Families: Molecular Bases of the Functional Diversity.- 7 Pharmacology of Voltage-Gated Potassium Channels.- 8 Voltage-Gated Calcium-Modulated Potassium Channels of Large Unitary Conductance: Structure, Diversity, and Pharmacology.- 9 Classical Inward Rectifying Potassium Channels: Mechanisms of Inward Rectification.- 10 ATP-Dependent Potassium Channels in the Kidney.- 11 Structure and Function of ATP-Sensitive K+ Channels.- 12 G Protein-Gated K+ Channels.- 13 Potassium Channels with Two Pore Domains.- 14 Cardiac K+ Channels and Inherited Long QT Syndrome.- Section II: Ligand Operated Ion Channels.- 15 Gating of Ion Channels by Transmitters: The Range of Structures of the Transmitter-Gated Channels.- 16 Molecular Diversity, Structure, and Function of Glutamate Receptor Channels.- 17 Glutamate Receptor Ion Channels: Activators and Inhibitors.- 18 Structure, Diversity, Pharmacology, and Pathology of Glycine Receptor Chloride Channels.- 19 GABAA Receptor Chloride Ion Channels.- 20 P2X Receptors for ATP: Classification, Distribution, and Function.- 21 The 5-HT3 Receptor Channel: Function, Activation and Regulation.- 22 Cyclic Nucleotide-Gated Channels: Classification, Structure and Function, Activators and Inhibitors.- Section III: Miscellaneous Ion Channels - Intracellular Ca Release Channels.- 23 Regulation of Ryanodine Receptor Calcium Release Channels.- 24 Regulation of IP3 Receptor Ca2+ Release Channels.- 25 Ca2+-Activated Non-Selective Cation Channels.
Section I: Voltage-Dependent Ion Channels.- A. Voltage-Dependent Na Channels.- 1 Structure and Functions of Voltage-Dependent Na+ Channels.- 2 Sodium Channel Blockers and Activators.- B. Voltage-Dependent Ca-Channels.- 3 Classification and Function of Voltage-Gated Calcium Channels.- Structure of the Voltage-Dependent L-Type Calcium Channel.- 5 Ca2+ Channel Antagonists and Agonists.- C. Voltage-Dependent K-Channels.- 6 Overview of Potassium Channel Families: Molecular Bases of the Functional Diversity.- 7 Pharmacology of Voltage-Gated Potassium Channels.- 8 Voltage-Gated Calcium-Modulated Potassium Channels of Large Unitary Conductance: Structure, Diversity, and Pharmacology.- 9 Classical Inward Rectifying Potassium Channels: Mechanisms of Inward Rectification.- 10 ATP-Dependent Potassium Channels in the Kidney.- 11 Structure and Function of ATP-Sensitive K+ Channels.- 12 G Protein-Gated K+ Channels.- 13 Potassium Channels with Two Pore Domains.- 14 Cardiac K+ Channels and Inherited Long QT Syndrome.- Section II: Ligand Operated Ion Channels.- 15 Gating of Ion Channels by Transmitters: The Range of Structures of the Transmitter-Gated Channels.- 16 Molecular Diversity, Structure, and Function of Glutamate Receptor Channels.- 17 Glutamate Receptor Ion Channels: Activators and Inhibitors.- 18 Structure, Diversity, Pharmacology, and Pathology of Glycine Receptor Chloride Channels.- 19 GABAA Receptor Chloride Ion Channels.- 20 P2X Receptors for ATP: Classification, Distribution, and Function.- 21 The 5-HT3 Receptor Channel: Function, Activation and Regulation.- 22 Cyclic Nucleotide-Gated Channels: Classification, Structure and Function, Activators and Inhibitors.- Section III: Miscellaneous Ion Channels - Intracellular Ca Release Channels.- 23 Regulation of Ryanodine Receptor Calcium Release Channels.- 24 Regulation of IP3 Receptor Ca2+ Release Channels.- 25 Ca2+-Activated Non-Selective Cation Channels.
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