Pharmacokinetics and Toxicokinetic Considerations explains the central principles, cutting-edge methodologies, and incipient thought processes applied to toxicology research. As part of the Advances in Pharmaceutical Product Development and Research series, the book provides expert literature on dose, dosage regimen and dose adjustment, medication errors, and approaches for its prevention, the concept of pharmacotherapy, and managed care in clinical interventions. It expounds on strategies to revamp the pharmacokinetics of the drug and the factors affecting the stability of drugs and their…mehr
Pharmacokinetics and Toxicokinetic Considerations explains the central principles, cutting-edge methodologies, and incipient thought processes applied to toxicology research. As part of the Advances in Pharmaceutical Product Development and Research series, the book provides expert literature on dose, dosage regimen and dose adjustment, medication errors, and approaches for its prevention, the concept of pharmacotherapy, and managed care in clinical interventions. It expounds on strategies to revamp the pharmacokinetics of the drug and the factors affecting the stability of drugs and their metabolites in biological matrices. Finally, the book offers focused elaborations on various bioanalytical methods for bioavailability and bioequivalence assessment and integrates the wide-ranging principles and concepts shared by toxicokinetics and pharmacodynamics as mutual crosstalk rather than isolated observations. It will be helpful to researchers and advanced students working in the pharmaceutical, cosmetics, biotechnology, food, and related industries including toxicologists, pharmacists, and pharmacologists.
Dr Rakesh K Tekade, Assistant Professor of the Department of Pharmaceutics, investigates the design, development and characterization of targeted nanotechnology based formulations for the site specific delivery of therapeutic drugs, siRNA, microRNA, plasmids, proteins and peptide for the treatment of cancer. His current research encompasses development of novel polymeric nanomaterial for effective cytosolic delivery of anticancer bioactives. Dr Tekade's research is focused on designing a new generation of nanoparticles, which could identify the cancer cells and selectively deliver anticancer drugs and genes to inhibit the growth of cancer while sparing healthy tissues. His research work involves the applications of polymer chemistry, nanotechnology, molecular biology, pharmacokinetics/pharmacodynamics and imaging techniques. Dr Tekade has over 70 publications, 01 patent, 7 book chapters, and 3 editorial articles. He has delivered several invited research talks and presented research finding in more than 30 scientific conferences.
Inhaltsangabe
1. Basic principles and concept in Toxicokinetic 2. Factors Influencing Drug Toxicity 3. Molecular biology of apoptotic, necrotic and necroptotic cell death 4. Toxicogenomic in drug safety assessment 5. Understanding the concept of signal toxicity 6. Importance of toxicity testing 7. Methods and Models for in vitro toxicity 8. New Emerging technologies for genetic toxicity testing 9. Zebrafish models for toxicological screening 10. Impact of ageing on the pharmacokinetics and pharmacodynamics of the drugs 11. Food-Drug Interactions and their Implications on Oral Drug Bioavailability 12. Drug-Drug interactions and their implications on the Pharmacokinetics of the Drugs 13. Clinical Importance of Herb-Drug interaction 14. Insilico methods for the prediction of drug toxicity 15. Organ-on-a-chip for assessing environmental toxicants 16. Toxicity and toxicokinetics consideration in product development and drug research 17. Drug Toxicity and Forensic Pharmacokinetics 18. Excipient's toxicity and safety 19. Pharmaceutical excipients: Special focus on Adverse drug interactions 20. Emerging role of novel excipients in drug product development and their safety concerns 21. Toxicity of Pharmaceutical azo dyes 22. Environmental and Safety Aspects of Bionanotechnology 23. Toxicological Risk assessment of medical devices 24. Developmental toxicity of nanomaterials used in healthcare 25. Ethical defilements in clinical research and potential roles of Institutional review board 26. Toxicodynamic in Drug research
1. Basic principles and concept in Toxicokinetic 2. Factors Influencing Drug Toxicity 3. Molecular biology of apoptotic, necrotic and necroptotic cell death 4. Toxicogenomic in drug safety assessment 5. Understanding the concept of signal toxicity 6. Importance of toxicity testing 7. Methods and Models for in vitro toxicity 8. New Emerging technologies for genetic toxicity testing 9. Zebrafish models for toxicological screening 10. Impact of ageing on the pharmacokinetics and pharmacodynamics of the drugs 11. Food-Drug Interactions and their Implications on Oral Drug Bioavailability 12. Drug-Drug interactions and their implications on the Pharmacokinetics of the Drugs 13. Clinical Importance of Herb-Drug interaction 14. Insilico methods for the prediction of drug toxicity 15. Organ-on-a-chip for assessing environmental toxicants 16. Toxicity and toxicokinetics consideration in product development and drug research 17. Drug Toxicity and Forensic Pharmacokinetics 18. Excipient's toxicity and safety 19. Pharmaceutical excipients: Special focus on Adverse drug interactions 20. Emerging role of novel excipients in drug product development and their safety concerns 21. Toxicity of Pharmaceutical azo dyes 22. Environmental and Safety Aspects of Bionanotechnology 23. Toxicological Risk assessment of medical devices 24. Developmental toxicity of nanomaterials used in healthcare 25. Ethical defilements in clinical research and potential roles of Institutional review board 26. Toxicodynamic in Drug research
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