Pharmaceutical Toxicology in Practice
A Guide to Non-Clinical Development
Herausgeber: Lodola, Alberto; Stadler, Jeanne
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A practical guide and up-to-datereference to toxicology testing Toxicology is not only an integral part of the identification of drug candidates, structural optimization, and lead candidate selection, but it is a cornerstone of managing attrition in the drug discovery process. This book describes the background to, and conduct of, the principal non-clinical studies that are central to drug development. Written by two highly experienced toxicologists, Pharmaceutical Toxicology in Practice: A Guide to Non-Clinical Development provides an understanding of the key components of the non-clinical ph...
A practical guide and up-to-datereference to toxicology testing Toxicology is not only an integral part of the identification of drug candidates, structural optimization, and lead candidate selection, but it is a cornerstone of managing attrition in the drug discovery process. This book describes the background to, and conduct of, the principal non-clinical studies that are central to drug development. Written by two highly experienced toxicologists, Pharmaceutical Toxicology in Practice: A Guide to Non-Clinical Development provides an understanding of the key components of the non-clinical phase of drug development. Taking a hands-on approach, the book's core chapters address conduct, types, and reporting. Opening with a practical description of toxicology and its role in the development of pharmaceuticals, the book details: * International regulations, including the impact of the new REACH standards for chemical safety * Interdisciplinary interactions among scientists in drug development * Steps in toxicity testing and risk management * Methods of genetic toxicology?assays, genomics, and in vivo screening as a complement to traditional toxicology By exploring the roles and responsibilities of the interdisciplinary members of a drug development team, Pharmaceutical Toxicology in Practice will help the drug development scientist to understand the toxicological profile of the test compound; the drug discovery scientist to refine the chemical motif of the test compound to optimize efficacy and reduce side effects; and the drug development team to advance the test compound to the clinic and then to the marketplace and the patient.
