Tsai

Microdialysis

• Gebundenes Buch

Produktbeschreibung

Applications of Microdialysis in Pharmaceutical Science focuses on the use of microdialysis in drug evaluation for different organs and tissues and pharmacokinetics. Introducing the basic principles of microdialysis, the book also covers quantification and validation, analytical considerations, pharmacodynamic studies, pharmacokinetics, clinical aspects, and other applications of microdialysis. Ideal for analytical chemists, pharmacists, and pharmacologists, this book uses easy-to-understand models and examples for readers, as well as thorough coverage of applications of microdialysis in preclinical and clinical evaluation of drug pharmacology.

Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 584
• Erscheinungstermin: 23. August 2011
• Englisch
• Abmessung: 240mm x 161mm x 36mm
• Gewicht: 1035g
• ISBN-13: 9780470409282
• ISBN-10: 0470409282
• Artikelnr.: 33393141

Autorenporträt

Tung-Hu Tsai, PhD, is a Professor at the Institute of Traditional Medicine, National Yang-Ming University, Taiwan. He has published more than 200 papers in the field of pharmaceutical analysis, herbal medicine, and pharmacokinetics. Dr. Tsai's current research focuses on the mechanisms of pharmacokinetic pathways, emphasizing hepatobiliary excretion and barrier transportation.

Inhaltsangabe

Contributors xi 1. Introduction to Applications of Microdialysis in
Pharmaceutical Science 1 Tung-Hu Tsai 2. Microdialysis in Drug Discovery 7
Christian Höcht 1. Introduction 7 2. Phases of Drug Development 8 3. Role
of Biomarkers in Drug Development 11 4. Role of
Pharmacokinetic-Pharmacodynamic Modeling in Drug Development 12 5. Role of
Microdialysis in Drug Development 15 6. Microdialysis Sampling in the Drug
Development of Specific Therapeutic Groups 20 7. Regulatory Aspects of
Microdialysis Sampling in Drug Development 29 8. Conclusions 30 3.
Analytical Considerations for Microdialysis Sampling 39 Pradyot Nandi,
Courtney D. Kuhnline, and Susan M. Lunte 1. Introduction 39 2. Analytical
Methodologies 49 3. Conclusions 75 4. Monitoring Dopamine in the
Mesocorticolimbic and Nigrostriatal Systems by Microdialysis: Relevance for
Mood Disorders and Parkinson's Disease 93 Giuseppe Di Giovanni, Massimo
Peirucci, and Vincenzo Di Matteo 1. Introduction 93 2. Pathophysiology of
Serotonin-Dopamine Interaction: Implication for Mood Disorders 94 3.
Dopamine Depletion in the Nigrostratal System: Parkinson's Disease 109 4.
Conclusions 120 5. Monitoring Neutrotransmitter Amino Acids by
Microdialysis: Pharmacodynamic Applications 151 Sandrine Parrot, Bernard
Renaud, Luc Zimmer, and Luc Denoroy 1. Introduction 151 2. Monitoring
Neurotransmitter Amino Acids by Microdialysis 152 3. Basic Research on
Receptors 162 4. Psychostimulants and Addictive Drugs 168 5. Analgesia 177
6. Ischemia-Anoxia 182 7. Conclusions and Perspectives 188 6. Microdialysis
as a Tool to Unravel Neurobiological Mechanisms of Seizures and
Antiepileptic Drug Action 207 Ilse Smolders, Ralph Clickers, and Yvette
Michotte 1. Introduction 207 2. Microdialysis to Characterize
Seizure-Related Neurobiological and Metabolic Changes in Animal Models and
in Humans 209 3. Microdialysis as a Chemoconvulsant Delivery Tool in Animal
Seizure Models 217 4. Microdialysis Used to Elucidate Mechanisms of
Electrical Brain Stimulation and Neuronal Circuits Involved in Seizures 218
5. Microdialysis Used to Unravel the Mechanisms of Action of Established
Antiepileptic Drugs and New Therapeutic Strategies 219 6. Microdialysis
Studies in the Search for Mechanisms of Adverse Effects of Clinically Used
Drugs, Drugs of Abuse, and Toxins 224 7. Combining Microdialysis with Other
Complementary Neurotechniques to Unravel Mechanisms of Seizures and
Epilepsy 226 8. The Advantage of Microdialysis Used to Sample Biophase
Antiepileptic Drug Levels and to Monitor Neurotransmitters as Markers for
Anticonvulsant Activity 228 9. Microdialysis Used to Study Relationships
Between Epilepsy and Its Comorbidities 236 7. Microdialysis in Lung Tissue:
Monitoring of Exogenous and Endogenous Compounds 255 Thomas Feurstein and
Markus Zeitlinger 1. Introduction 255 2. Special Aspects Associated with
Lung Microdialysis Compared to Microdialysis in Other Tissues 252 3.
Insertion of Microdialysis Probes into Lung Tissue 256 4. Insertion of
Microdialysis Probes into the Bronchial System 257 5. Types of Probes 258
6. Endogenous Compounds 258 7. Exogenous Drugs 259 8. Animal Data 260 9.
Clinical Data 262 10. Comparison of Pharmacokinetic Data in Lung Obtained
by Microdialysis and Other Techniques 264 11. Predictability of Lung
Concentrations by Measurements on Other Tissues 265 8. Microdialysis in the
Hepatobility System: Monitoring Drug Metabolism, Hepatebiliary Excretion,
and Enterohepatic Circulation 275 Yu-Tse Wu and Tung-Hu Tsia 1.
Introduction 275 2. Experimental Considerations of Pharmacokinetic Studies
279 3. Pharmacokinetic and Hepatobiliary Excretion Studies Emproving
Microdialysis 284 4. Conclusions 287 9. Microdialysis Used to Measure the
Metabolism of Glucose, Lactate, and Glycerol 295 Greg Nowak 1.Introduction
295 2. Glucose 299 3. Lactate 301 4. Lactate/Pyruvate Ratio 303 5. Glycerol
303 10. Clinical Microdialysis in Skin and Soft Tissues 313 Martina Sahre,
Runa Naik, and Hartmut Derendorf 1. Introduction 313 2. Tissue
Bioavailability 314 3. PK-PD Indices 323 4. Topical Bioequivalence 329 5.
Endogenous Compounds 330 6. Conclusion 331 11. Microdialysis on Adipose
Tissue: Monitoring Tissue Metabolism and Blood Flow in Humans 335 Gijs H.
Goossens, Wim H. Saris, and Ellen E. Black 1. Introduction 335 2.
Principles and Practical Considerations in the Use of Microdialysis on
Adipose Tissue 336 3. Use of Microdialysis on Adipose Tissue in Humans 342
4. Summary and Conclusions 353 12. Microdialysis as a Monitoring System for
Human Diabetes 359 Anna Ciechanowska, Jan M. Wojcick, Iwuna
Maruniak-Chudek,Piotr Ladyzynski, and Janusz Kraybien 1. Introduction 359
2. Monitoring Acute Complications of Diabetes 362 13. Microdialysis Use in
Tumors Drug Disposition and Tumor Response 403 Quigyu Zhou and James M.
Gallo 1. Introduction 403 2. Microdialysis as a Sampling Technique in
Oncology 404 3. Experimental Considerations 408 4. Examples of the Use of
Microdualysis to Characterize Drug Disposition in Tumor 414 5. Use of
Microdialysis in the Evaluation of Tumor Response to Therapy 423 6.
Conclusions and Future Perspectives 423 14. Microdialysis Versus Imaging
Techniques for In Vivo Drug Distribution Measurements 431 Martin Brunner 1.
Introduction 431 2. Microdialysis 432 3. Imaging Techniques 434 4. Magnetic
Resonance Imaging and Magnetic Resonance Spectroscopy 434 5.
Positron-Emission Tomography 435 6. Combination of Microdialysis and
Imaging Techniques 436 7. Summary and Conclusions 438 15. In Vitro
Applications of Microdialysis 445 Wen-Chuan Lee and Tung-Hu Tsai 1.
Introduction 445 2. Microdialysis Used in Culture Systems 446 3.
Microdialysis Used in Enzyme Kinetics 453 4. Microdialysis Used in Protein
Binding 455 5. Conclusions 456 16. Microdialysis in Drug-Drug Interaction
465 Mitsuhito Wada, Rie Ikeda, and Kenichiro Nakashima 1. Introduction 465
2. Pharmacokinetic Drug-Drug Interaction 472 3. Pharmacodynamic Drug-Drug
Interaction 487 4. Conclusions 501 17. Microdialysis in Environmental
Monitoring 509 Manuel Miró and Wolfgang Frenzel 1. Introduction 509 2. In
Vivo and In Situ Sampling: Similarities and Differences 510 3. Critical
Parameters Influencing Relative Recoveries 513 4. Detection Techniques 516
5. Calibration Methods 519 6. Environmental Applications of Microdialysis
520 7. Conclusions and Future Trends 524 Index 531