Peptide spielen eine entscheidende Rolle in vielen physiologischen Prozessen, sei es als Neurotransmitter, Hormone oder Antibiotika. Angesichts der rasanten Entwicklung der Peptidforschung in den letzten Jahrzehnten ist sie für Einsteiger in ihrem gegenwärtigen Ausmaß kaum noch überschaubar. Deshalb ist eine gut verständliche, präzise Einführung unabdingbar.
Dieses Werk deckt alle wichtigen Aspekte dieses weit verzweigten Gebietes in einem kompakten Band ab. Auf Basis der grundlegenden chemischen und strukturellen Eigenschaften von Peptiden spannt es den Bogen von der Analyse, dem Vorkommen und der biologischen Bedeutung von Peptiden über chemische, biochemische und gentechnologische Verfahren zur Peptidsynthese bis hin zu Peptidbibliotheken, Peptiddesign und der Stellung von Peptiden in der Arzneimittelforschung. Doch bietet dieses Buch weit mehr als einen reinen Überblick über den aktuellen Stand der Forschung: Ein einzigartiger lexikalischer Anhang mit wertvollen Informationen zu mehr als 500 biologisch relevanten Peptiden und Proteinen, ein umfangreiches Register und Angaben zu weiterführender Literatur machen es zu einem idealen Nachschlagewerk bei allen Fragen zur Peptidforschung. Ein konkurrenzloses Werk, von dem sowohl Neueinsteiger als auch Spezialisten profitieren werden.
"N.Sewald und H.-D. Jakubke haben ein bemerkenswertes Buch über die Chemie und Biologie von Peptiden verfasst, das eine wertvolle Bereicherung für die Bibliothek eines jeden Peptidchemikers ist, der in diesem schnell wachsenden Gebiet auf dem Laufenden bleiben will ... Das Buch ist sorgfältig verfasst und redigiert ... Ein gut geordnetes Inhaltsverzeichnis, eine Liste mit Abkürzungen und ein Stichwortverzeichnis sind besonders für den Leser hilfreich, der das Buch als Nachschlagewerk nutzen will ... Zusammenfassend ist festzustellen, dass diese von Experten auf dem Gebiet der Peptide geschriebene Monographie in Fachkreisen dankbar angenommen und eine weite Verbreitung finden wird." Bruce Merrifield, The Rockefeller University, New York
"Es macht Sinn, sowohl die Chemie als auch die Biologie in einem Buch zusammenzufassen, zumal dies hier in besonders hervorragender Weise gelungen ist. Das Buch, welches durch viele Details überzeugt (z.B. mit dem Glossar), lässt keine Wünsche offen. "Peptides: Chemistry and Biology" präsentiert alle wichtigen Fakten zum Thema Peptide und verweist zu jedem Kapitel auf eine Vielzahl an weiterführender Literatur. Das Buch ist für Chemiker, welche auf dem Gebiet arbeiten, überaus empfehelenswert."
www.organische-chemie.ch
INTRODUCTION AND BACKGROUND
FUNDAMENTAL CHEMICAL AND STRUCTURAL PRINCIPLES
Definitions and main conformational features of the peptide bond
Building blocks, classification and nomenclature
Analysis of the covalent structure of peptides and proteins
Three-dimensional structure
Methods of structural analysis
BIOLOGICALLY ACTIVE PEPTIDES
Occurrence and biological roles
Biosynthesis
Selected bioactive peptide families
PEPTIDE SYNTHESIS
Principles and objectives
Protection of functional groups
Peptide bond formation
Racemization during synthesis
Solid phase peptide synthesis (SPPS)
Biochemical synthesis
SYNTHESIS CONCEPTS FOR PEPTIDES AND PROTEINS
Strategy and tactics
Synthesis in solution
Optimized strategies on polymeric support
Ligation of unprotected peptide segments
SYNTHESIS OF SPECIAL PEPTIDES AND PEPTIDE CONJUGATES
Cyclopeptides
Cystine peptides
Glycopeptides
Phosphopeptides
Lipopeptides
Sulfated peptides
PEPTIDE AND PROTEIN DESIGN, PSEUDOPEPTIDES, PEPTIDOMIMETICS
Peptide design
Modified peptides
Peptidomimetics
Pseudobiopolymers
Macropeptides and de novo design of peptides and proteins
COMBINATORIAL SYNTHESIS
Parallel synthesis
Synthesis of mixtures
APPLICATION OF PEPTIDES AND PROTEINS
Protein pharmaceuticals
Large scale peptide synthesis
Peptide pharmaceuticals
Peptide drugs and new drug assays
Peptides play a decisive role in many physiological processes, whether as neurotransmitters, hormones or antibiotics. The rapid developments in peptide research over the past few decades make it almost impossible for newcomers to gain an overview. This means an easily comprehensible yet concise introduction is vital.
This unique work covers all the important aspects of this wide-ranging field in one handy volume. On the basis of the fundamental chemical and structural properties of peptides, this reference runs the gamut from analysis, the occurrence and biological importance of peptides, via chemical, biochemical and genetic methods of peptide synthesis, right up to peptide libraries, peptide design and their role in drug research. Yet this book offers much more than a mere overview of the latest level of research. An encyclopedic appendix with valuable data on more than 500 biological relevant peptides and proteins, a comprehensive register and details of further literature references make this the ideal reference for all questions regarding peptide research. For newcomers and specialists alike.
"The book by Sewald and Jakubke is most timely and will be extremely useful for students and researchers in peptide science. The authors address the broad fundamentals of peptide synthesis and structure. They also identify important families of biologically active peptides.
Lastly, they bring their impressive treatment up to the most current of peptide activities including pseudopeptides, peptidomimetics, combinatorial syntheses and applications of peptides as pharmaceuticals and in biotechnology. The book is an impressive addition to the field and will help researchers identify peptide derivatives as key target molecules for pharmaceuticals and novel structures in biotechnology." Murray Goodman, Univ. of California, San Diego
"Sewald and Jakubke have produced a remarkable volume on the chemistry and biology of peptides, which will be a valuable addition to the library of peptide chemists who want to keep abreast of this rapidly growing area ... This is a most carefully written and edited volume ... All of this large amount of information is documented by some 1500 references to the relevant publications selected from a much larger literature ... A detailed table of contents, a list of abbreviations, and a subject index are included and are very helpful, especially when the book is used as a reference volume ... It comes through clearly that this monograph is written by experts who are experienced in the peptide field and it will be widely accepted." Bruce Merrifield, Department of Biochemistry, The Rockefeller University, New York
"In this book, all .. topics are nicely arranged and discussed, including definition, nomenclature, isolation, purification, structure definition, conformation, spectroscopy, and biological activity...
An additional feature of the book is the inclusion of a concise glossary listing in 114 pages more than 500 biologically active peptides, in which the origin, amino acid structure, biological activity, and key references are summarized. The book is strongly recommended to students and researchers who would like to study peptide chemistry, in as much as it contains a comprehensive review and an encyclopedia of useful information relating to all aspects of peptide science." Shumpei Sakakibara, Protein Research Foundation, Minoh, Osaka, Japan
"This absolutely excellent book, handsomely produced and underpriced at £60, - which all students of any aspect of peptone science ought to have within arm's reach"
- The European Peptide Society Newsletter, January 2003, No. 28
INTRODUCTION AND BACKGROUND
FUNDAMENTAL CHEMICAL AND STRUCTURAL PRINCIPLES
Definitions and main conformational features of the peptide bond
Building blocks, classification and nomenclature
Analysis of the covalent structure of peptides and proteins
Three-dimensional structure
Methods of structural analysis
BIOLOGICALLY ACTIVE PEPTIDES
Occurrence and biological roles
Biosynthesis
Selected bioactive peptide families
PEPTIDE SYNTHESIS
Principles and objectives
Protection of functional groups
Peptide bond formation
Racemization during synthesis
Solid phase peptide synthesis (SPPS)
Biochemical synthesis
SYNTHESIS CONCEPTS FOR PEPTIDES AND PROTEINS
Strategy and tactics
Synthesis in solution
Optimized strategies on polymeric support
Ligation of unprotected peptide segments
SYNTHESIS OF SPECIAL PEPTIDES AND PEPTIDE CONJUGATES
Cyclopeptides
Cystine peptides
Glycopeptides
Phosphopeptides
Lipopeptides
Sulfated peptides
PEPTIDE AND PROTEIN DESIGN, PSEUDOPEPTIDES, PEPTIDOMIMETICS
Peptide design
Modified peptides
Peptidomimetics
Pseudobiopolymers
Macropeptides and de novo design of peptides and proteins
COMBINATORIAL SYNTHESIS
Parallel synthesis
Synthesis of mixtures
APPLICATION OF PEPTIDES AND PROTEINS
Protein pharmaceuticals
Large scale peptide synthesis
Peptide pharmaceuticals
Peptide drugs and new drug assays
Dieses Werk deckt alle wichtigen Aspekte dieses weit verzweigten Gebietes in einem kompakten Band ab. Auf Basis der grundlegenden chemischen und strukturellen Eigenschaften von Peptiden spannt es den Bogen von der Analyse, dem Vorkommen und der biologischen Bedeutung von Peptiden über chemische, biochemische und gentechnologische Verfahren zur Peptidsynthese bis hin zu Peptidbibliotheken, Peptiddesign und der Stellung von Peptiden in der Arzneimittelforschung. Doch bietet dieses Buch weit mehr als einen reinen Überblick über den aktuellen Stand der Forschung: Ein einzigartiger lexikalischer Anhang mit wertvollen Informationen zu mehr als 500 biologisch relevanten Peptiden und Proteinen, ein umfangreiches Register und Angaben zu weiterführender Literatur machen es zu einem idealen Nachschlagewerk bei allen Fragen zur Peptidforschung. Ein konkurrenzloses Werk, von dem sowohl Neueinsteiger als auch Spezialisten profitieren werden.
"N.Sewald und H.-D. Jakubke haben ein bemerkenswertes Buch über die Chemie und Biologie von Peptiden verfasst, das eine wertvolle Bereicherung für die Bibliothek eines jeden Peptidchemikers ist, der in diesem schnell wachsenden Gebiet auf dem Laufenden bleiben will ... Das Buch ist sorgfältig verfasst und redigiert ... Ein gut geordnetes Inhaltsverzeichnis, eine Liste mit Abkürzungen und ein Stichwortverzeichnis sind besonders für den Leser hilfreich, der das Buch als Nachschlagewerk nutzen will ... Zusammenfassend ist festzustellen, dass diese von Experten auf dem Gebiet der Peptide geschriebene Monographie in Fachkreisen dankbar angenommen und eine weite Verbreitung finden wird." Bruce Merrifield, The Rockefeller University, New York
"Es macht Sinn, sowohl die Chemie als auch die Biologie in einem Buch zusammenzufassen, zumal dies hier in besonders hervorragender Weise gelungen ist. Das Buch, welches durch viele Details überzeugt (z.B. mit dem Glossar), lässt keine Wünsche offen. "Peptides: Chemistry and Biology" präsentiert alle wichtigen Fakten zum Thema Peptide und verweist zu jedem Kapitel auf eine Vielzahl an weiterführender Literatur. Das Buch ist für Chemiker, welche auf dem Gebiet arbeiten, überaus empfehelenswert."
www.organische-chemie.ch
INTRODUCTION AND BACKGROUND
FUNDAMENTAL CHEMICAL AND STRUCTURAL PRINCIPLES
Definitions and main conformational features of the peptide bond
Building blocks, classification and nomenclature
Analysis of the covalent structure of peptides and proteins
Three-dimensional structure
Methods of structural analysis
BIOLOGICALLY ACTIVE PEPTIDES
Occurrence and biological roles
Biosynthesis
Selected bioactive peptide families
PEPTIDE SYNTHESIS
Principles and objectives
Protection of functional groups
Peptide bond formation
Racemization during synthesis
Solid phase peptide synthesis (SPPS)
Biochemical synthesis
SYNTHESIS CONCEPTS FOR PEPTIDES AND PROTEINS
Strategy and tactics
Synthesis in solution
Optimized strategies on polymeric support
Ligation of unprotected peptide segments
SYNTHESIS OF SPECIAL PEPTIDES AND PEPTIDE CONJUGATES
Cyclopeptides
Cystine peptides
Glycopeptides
Phosphopeptides
Lipopeptides
Sulfated peptides
PEPTIDE AND PROTEIN DESIGN, PSEUDOPEPTIDES, PEPTIDOMIMETICS
Peptide design
Modified peptides
Peptidomimetics
Pseudobiopolymers
Macropeptides and de novo design of peptides and proteins
COMBINATORIAL SYNTHESIS
Parallel synthesis
Synthesis of mixtures
APPLICATION OF PEPTIDES AND PROTEINS
Protein pharmaceuticals
Large scale peptide synthesis
Peptide pharmaceuticals
Peptide drugs and new drug assays
Peptides play a decisive role in many physiological processes, whether as neurotransmitters, hormones or antibiotics. The rapid developments in peptide research over the past few decades make it almost impossible for newcomers to gain an overview. This means an easily comprehensible yet concise introduction is vital.
This unique work covers all the important aspects of this wide-ranging field in one handy volume. On the basis of the fundamental chemical and structural properties of peptides, this reference runs the gamut from analysis, the occurrence and biological importance of peptides, via chemical, biochemical and genetic methods of peptide synthesis, right up to peptide libraries, peptide design and their role in drug research. Yet this book offers much more than a mere overview of the latest level of research. An encyclopedic appendix with valuable data on more than 500 biological relevant peptides and proteins, a comprehensive register and details of further literature references make this the ideal reference for all questions regarding peptide research. For newcomers and specialists alike.
"The book by Sewald and Jakubke is most timely and will be extremely useful for students and researchers in peptide science. The authors address the broad fundamentals of peptide synthesis and structure. They also identify important families of biologically active peptides.
Lastly, they bring their impressive treatment up to the most current of peptide activities including pseudopeptides, peptidomimetics, combinatorial syntheses and applications of peptides as pharmaceuticals and in biotechnology. The book is an impressive addition to the field and will help researchers identify peptide derivatives as key target molecules for pharmaceuticals and novel structures in biotechnology." Murray Goodman, Univ. of California, San Diego
"Sewald and Jakubke have produced a remarkable volume on the chemistry and biology of peptides, which will be a valuable addition to the library of peptide chemists who want to keep abreast of this rapidly growing area ... This is a most carefully written and edited volume ... All of this large amount of information is documented by some 1500 references to the relevant publications selected from a much larger literature ... A detailed table of contents, a list of abbreviations, and a subject index are included and are very helpful, especially when the book is used as a reference volume ... It comes through clearly that this monograph is written by experts who are experienced in the peptide field and it will be widely accepted." Bruce Merrifield, Department of Biochemistry, The Rockefeller University, New York
"In this book, all .. topics are nicely arranged and discussed, including definition, nomenclature, isolation, purification, structure definition, conformation, spectroscopy, and biological activity...
An additional feature of the book is the inclusion of a concise glossary listing in 114 pages more than 500 biologically active peptides, in which the origin, amino acid structure, biological activity, and key references are summarized. The book is strongly recommended to students and researchers who would like to study peptide chemistry, in as much as it contains a comprehensive review and an encyclopedia of useful information relating to all aspects of peptide science." Shumpei Sakakibara, Protein Research Foundation, Minoh, Osaka, Japan
"This absolutely excellent book, handsomely produced and underpriced at £60, - which all students of any aspect of peptone science ought to have within arm's reach"
- The European Peptide Society Newsletter, January 2003, No. 28
INTRODUCTION AND BACKGROUND
FUNDAMENTAL CHEMICAL AND STRUCTURAL PRINCIPLES
Definitions and main conformational features of the peptide bond
Building blocks, classification and nomenclature
Analysis of the covalent structure of peptides and proteins
Three-dimensional structure
Methods of structural analysis
BIOLOGICALLY ACTIVE PEPTIDES
Occurrence and biological roles
Biosynthesis
Selected bioactive peptide families
PEPTIDE SYNTHESIS
Principles and objectives
Protection of functional groups
Peptide bond formation
Racemization during synthesis
Solid phase peptide synthesis (SPPS)
Biochemical synthesis
SYNTHESIS CONCEPTS FOR PEPTIDES AND PROTEINS
Strategy and tactics
Synthesis in solution
Optimized strategies on polymeric support
Ligation of unprotected peptide segments
SYNTHESIS OF SPECIAL PEPTIDES AND PEPTIDE CONJUGATES
Cyclopeptides
Cystine peptides
Glycopeptides
Phosphopeptides
Lipopeptides
Sulfated peptides
PEPTIDE AND PROTEIN DESIGN, PSEUDOPEPTIDES, PEPTIDOMIMETICS
Peptide design
Modified peptides
Peptidomimetics
Pseudobiopolymers
Macropeptides and de novo design of peptides and proteins
COMBINATORIAL SYNTHESIS
Parallel synthesis
Synthesis of mixtures
APPLICATION OF PEPTIDES AND PROTEINS
Protein pharmaceuticals
Large scale peptide synthesis
Peptide pharmaceuticals
Peptide drugs and new drug assays
"The book by Sewald and Jakubke is most timely and will be extremely useful for students and researchers in peptide science. The authors address the broad fundamentals of peptide synthesis and structure. They also identify important families of biologically active peptides.
Lastly, they bring their impressive treatment up to the most current of peptide activities including pseudopeptides, peptidomimetics, combinatorial syntheses and applications of peptides as pharmaceuticals and in biotechnology. The book is an impressive addition to the field and will help researchers identify peptide derivatives as key target molecules for pharmaceuticals and novel structures in biotechnology." - Murray Goodman, Univ. of California, San Diego
Lastly, they bring their impressive treatment up to the most current of peptide activities including pseudopeptides, peptidomimetics, combinatorial syntheses and applications of peptides as pharmaceuticals and in biotechnology. The book is an impressive addition to the field and will help researchers identify peptide derivatives as key target molecules for pharmaceuticals and novel structures in biotechnology." - Murray Goodman, Univ. of California, San Diego