The 1992 Chinese Peptide Symposium was held at Hangzhou, China on November 3--6, 1992 with 152 participants, including 46 from abroad, representing 10 countries. The three days conference was both intense and spiritually rewarding. The Biennial Chinese Peptide Symposium was aimed to provide a forum for advancing the exchange of knowledge, cooperation and friendship between the international and Chinese scientific communities. In order to exchange ideas and review the latest progress in depth, the scientific sessions were held at the mornings and evenings, while afternoons were devoted to…mehr
The 1992 Chinese Peptide Symposium was held at Hangzhou, China on November 3--6, 1992 with 152 participants, including 46 from abroad, representing 10 countries. The three days conference was both intense and spiritually rewarding. The Biennial Chinese Peptide Symposium was aimed to provide a forum for advancing the exchange of knowledge, cooperation and friendship between the international and Chinese scientific communities. In order to exchange ideas and review the latest progress in depth, the scientific sessions were held at the mornings and evenings, while afternoons were devoted to social interaction and sightseeing of the unparalleled beauty of Westlake. For realizing the goal to catch up with a fast evolving and fascinating field, the Program Committee arranged eight sessions with 45 oral presentations and 72 posters on topics relating to peptide conformation, design, hormone and bioactive peptides, neuropeptides, recognition, synthesis and methodology in the Symposium and selected 94 articles for publication in this proceedings. As an organizer I was greatly encouraged by the active response of invited speakers and moved by enthusiastic cooperation and excellent contributions which led to the great success of the Symposium, since their presentations were of high quality and represented the latest advances in all aspects of peptide chemistry and peptide biology. Many authors concentrated their attention to a great challenge which peptide chemists have nowadays to face, i. e.
Session I: Peptide hormones.- Insulin analogue with substitutions at the C-terminus of the A-chain.- Insulin and IGF-I analogs: novel approaches to improved insulin pharmacokinetics.- Preparation and properties of [B2,Lys]-insulin and [B3,Lys]-insulin.- Biological activities of thymopentin, tuftsin and neurotensin(8-13) are profoundly influenced by metabolites resulting from enzymatic degradation of their retro-inverso analogues.- Production of inhibin by human luteal cells.- Synthesis of B22 Asp human insulin and its biological activity.- High level expression of human insulin genes in Escherichia coli.- Preparation and properties of [des(B1-3),B4-pGlu]-insulin and [des(B1-4)]-insulin.- Semisynthesis of insulin/IGF-I hybrid from desalanylinsulin.- Insulin analogues with alteration at two regions of the A chain.- Angiotensin II in the myocardium and aging.- Preparation and identification of [B1,2-Ala, Ala]-insulin.- Session II: Neuropeptides.- Structure-activity studies of LHRH antagonists with side-chain modified D-Lysine in position 6.- Effect of GABA on LHRH release in median eminence of rats.- Melanotropic peptides for the identification, localization (imaging) and chemotherapy of melanoma.- Binding capability of ZNC(C)PR and its effects on potentiation of synaptic transmission in rat hippocampus.- Novel oxytocin antagonists.- Mechanisms underlying the anti-opioid effect of cholesystokinin octapeptide (CCK-8) in central nervous system.- B-50/GAP-43 mRNA expression in adult rat hippocampus.- Interaction of Met-enkephalin-Arg6-Phe7 with phosphatidylserine.- Effects of central and peripheral brain natriuretic peptide (BNP) on aldosterone secretion.- Synthesis of human growth hormone releasing factor (GHRF) analogue with high activity.- Pyrogenic effect and muramyl peptides.- The interactions between human recombinant interleukin-2 (hrIL-2) and opioid receptors.- Session III: Immunopeptides.- Design of HIV protease inhibitors based on the transition state concept.- Studies on the detection of antibodies of HIV-1 by synthetic peptides.- Conformational studies on synthetic peptides from the principal neutralizing domain of HIV-1 Gp120 that bind to CD4 and enhance viral infectivity.- Synthetic gp41 peptides as sensitive and specific diagnostic reagents in HIV-1 infection.- The sporozoite surface antigen 2 of plasmodium yoelii contains a T and B cell epitope cross reacting with the repetitive sequence of the Plasmodium falciparum circumsporozoite protein.- Comparison of the antigenic activity of five hendecapeptides on trichosanthin and ?-momorcharin.- Effects of methionine enkephalin on splenocytes proliferation and electrophoresis rate in liver impaired mice.- Evidence for in vitro effect of methionine enkephalin on macrophages from liver impaired mice.- Regulatory effects of substance p and somatostatin on natural killer activity and macrophage tumoricidal activity in vitro.- Knowledge-based computer modelling for the N-terminal domain of carcinoembryonic antigen(CEA).- Poly(ethylene glycol) hybrids of RGD and YIGSR and theirinhibitory effect on experimental metastasis.- Session IV: Receptor and regulation.- Oligomerization in vitro of the extracellular domain of the insulin receptor by non-covalent interactions is accompanied by increased binding affinity, decreased binding capacity and curvilinear Scatchard plots.- Synthesis and insulin-receptor binding activity of two insulin-related peptides.- The studies on synthesis, bioactivity and paramagnetism application of spin labelled angiotensin (AngII-R).- Insulin receptor binding, insulin receptor kinase activity, and stimulation of insulin-like growth factor II binding to isolated rat adipocytes.- Structure-function relationships in the thrombin receptor agonist peptides.- Melanotropic peptides and melanoma cell receptors.- Isolation and purification of ?-opioid binding protein from rat brain.- Recognition and binding of anti-idiotypic anti-ohmefentanyl antibody to
Session I: Peptide hormones.- Insulin analogue with substitutions at the C-terminus of the A-chain.- Insulin and IGF-I analogs: novel approaches to improved insulin pharmacokinetics.- Preparation and properties of [B2,Lys]-insulin and [B3,Lys]-insulin.- Biological activities of thymopentin, tuftsin and neurotensin(8-13) are profoundly influenced by metabolites resulting from enzymatic degradation of their retro-inverso analogues.- Production of inhibin by human luteal cells.- Synthesis of B22 Asp human insulin and its biological activity.- High level expression of human insulin genes in Escherichia coli.- Preparation and properties of [des(B1-3),B4-pGlu]-insulin and [des(B1-4)]-insulin.- Semisynthesis of insulin/IGF-I hybrid from desalanylinsulin.- Insulin analogues with alteration at two regions of the A chain.- Angiotensin II in the myocardium and aging.- Preparation and identification of [B1,2-Ala, Ala]-insulin.- Session II: Neuropeptides.- Structure-activity studies of LHRH antagonists with side-chain modified D-Lysine in position 6.- Effect of GABA on LHRH release in median eminence of rats.- Melanotropic peptides for the identification, localization (imaging) and chemotherapy of melanoma.- Binding capability of ZNC(C)PR and its effects on potentiation of synaptic transmission in rat hippocampus.- Novel oxytocin antagonists.- Mechanisms underlying the anti-opioid effect of cholesystokinin octapeptide (CCK-8) in central nervous system.- B-50/GAP-43 mRNA expression in adult rat hippocampus.- Interaction of Met-enkephalin-Arg6-Phe7 with phosphatidylserine.- Effects of central and peripheral brain natriuretic peptide (BNP) on aldosterone secretion.- Synthesis of human growth hormone releasing factor (GHRF) analogue with high activity.- Pyrogenic effect and muramyl peptides.- The interactions between human recombinant interleukin-2 (hrIL-2) and opioid receptors.- Session III: Immunopeptides.- Design of HIV protease inhibitors based on the transition state concept.- Studies on the detection of antibodies of HIV-1 by synthetic peptides.- Conformational studies on synthetic peptides from the principal neutralizing domain of HIV-1 Gp120 that bind to CD4 and enhance viral infectivity.- Synthetic gp41 peptides as sensitive and specific diagnostic reagents in HIV-1 infection.- The sporozoite surface antigen 2 of plasmodium yoelii contains a T and B cell epitope cross reacting with the repetitive sequence of the Plasmodium falciparum circumsporozoite protein.- Comparison of the antigenic activity of five hendecapeptides on trichosanthin and ?-momorcharin.- Effects of methionine enkephalin on splenocytes proliferation and electrophoresis rate in liver impaired mice.- Evidence for in vitro effect of methionine enkephalin on macrophages from liver impaired mice.- Regulatory effects of substance p and somatostatin on natural killer activity and macrophage tumoricidal activity in vitro.- Knowledge-based computer modelling for the N-terminal domain of carcinoembryonic antigen(CEA).- Poly(ethylene glycol) hybrids of RGD and YIGSR and theirinhibitory effect on experimental metastasis.- Session IV: Receptor and regulation.- Oligomerization in vitro of the extracellular domain of the insulin receptor by non-covalent interactions is accompanied by increased binding affinity, decreased binding capacity and curvilinear Scatchard plots.- Synthesis and insulin-receptor binding activity of two insulin-related peptides.- The studies on synthesis, bioactivity and paramagnetism application of spin labelled angiotensin (AngII-R).- Insulin receptor binding, insulin receptor kinase activity, and stimulation of insulin-like growth factor II binding to isolated rat adipocytes.- Structure-function relationships in the thrombin receptor agonist peptides.- Melanotropic peptides and melanoma cell receptors.- Isolation and purification of ?-opioid binding protein from rat brain.- Recognition and binding of anti-idiotypic anti-ohmefentanyl antibody to
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