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The Guest Editors have assembled international experts in rheumatology to present an update to pediatricians. The basics are covered, including an article on the principles of inflammation in the child and one on the approach to the child with joint inflammation. From there, specifics are presented in the following articles: Laboratory Testing in Rheumatology; Rheumatologic Emergencies in newborns, children and adolescents; Juvenile Idiopathic Arthritis; Macrophage Activation Syndrome; Systemic Lupus Erythematosus; Idiopathic Inflammatory Myopathies in Childhood; Scleroderma; Vasculitis; Kawasaki disease; Autoinflammatory diseases; Approach to the patient with non-inflammatory musculoskeletal pain; and Immune deficiency diseases with rheumatic manifestations.