Seymour Glagov The last meeting, devoted exclusively to an examination of the atherosclerotic plaque, took place in Chicago 25 years ago under the joint auspices of the Council on Arteriosclerosis of the American Heart Association and the Chicago Heart Association. The proceedings were published subsequently in a volume entitled "Evolution of the Atherosclerotic Plaque", edited by Richard J. Jones (1). Both experimental and human lesions were considered and several provocative new approaches to the disorder were discussed. The electron microscope was being applied systematically to the study…mehr
Seymour Glagov The last meeting, devoted exclusively to an examination of the atherosclerotic plaque, took place in Chicago 25 years ago under the joint auspices of the Council on Arteriosclerosis of the American Heart Association and the Chicago Heart Association. The proceedings were published subsequently in a volume entitled "Evolution of the Atherosclerotic Plaque", edited by Richard J. Jones (1). Both experimental and human lesions were considered and several provocative new approaches to the disorder were discussed. The electron microscope was being applied systematically to the study of blood vessels at that time, so that details of the infrastructure and cellular composition of the artery wall and of atherosclerotic lesions were presented in some detail. There was, as one result of these explorations, considerable discussion of morphologic evidence suggesting that the principal cell involved in the atherogenic process was neither the fibroblast nor the macrophage, as hadbeen supposed, but the smooth muscle cell. In particular, the findings indicated that this cell could incorporate lipid and become a foam cell.
'1. Questions About the Natural History of Human Atherosclerosis.- Cellular Contents.- 2. Arterial Endothelial Structure and Permeability as It Relates to Susceptibility to Atherogenesis.- 3. Second Messengers in Human Vascular Endothelial Cells: Regulation of Endothelial Monolayer Formation and Repair.- 4. Cytoskeletal Characterization of Smooth Muscle Cells of Human and Experimental Atherosclerotic Plaques.- 5. Phenotypic Changes in Smooth Muscle Cells of Human Atherosclerotic Plaques.- 6. Changes in the Cells of Atherosclerotic Lesions as Advanced Lesions Evolve in Coronary Arteries of Children and Young Adults.- 7. Inflammatory Components of the Human Atherosclerotic Plaque.- 8. The Role of Macrophages in Human Atherosclerosis.- 9. Recent Observations on Human Atherosclerotic Lesions, and their Possible Significance.- Tissue Organization and Architecture.- 10. Intimal Lipids and Associated Changes in Intimal Composition.- 11. Evolution of the Atherosclerotic Plaque-A Physicochemical Approach to Lipid Deposition.- 12. Modification of Collagen and Elastin in the Human Atherosclerotic Plaque.- 13. Nature and Importance of Proteoglycans in the Atherosclerotic Plaque.- 14. Biochemical and Immunological Evidence for the Presence of Lipoprotein-Antilipoprotein Immune Complexes in Human Atherosclerotic Plaques.- 15. Mechanisms of Calcification in Atherosclerosis.- 16. Characterization of Nucleating Proteolipids from Calcified and Non-Calcified Atherosclerotic Lesions.- Pathobiologic Processes.- 17. The Problems of Procedures for the Study of the Pathological Processes of Human Atherosclerosis.- 18. Problems and Progress in Understanding "Endothelial Permeability" and Mass Transport in Human Arteries.- 19. Accumulating Evidence from Human Artery Studies of What Gets Transported and What Accumulates Relative to Atherogenesis.- 20. How Hemodynamic Forces in the Human Affect the Topography and Development of Atherosclerosis.- 21. What Do We Find in Human Atherosclerosis that Provides Insight into the Hemodynamic Factors in Atherogenesis?.- 22. Cell Births and Cell Deaths in the Human Atherosclerotic Plaque as Evaluated from Human Studies.- 23. Immunocytochemical Analysis of the Cellular Composition of Atherosclerotic Lesions in the Human Aorta.- 24. An Overview of Thrombosis and Platelet Involvement in the Development of the Human Atherosclerotic Plaque.- 25. Observations Regarding the Thrombotic Process in Human Subjects.- 26. Plaque Hemorrhages, Their Genesis and Their Role in Supra-Plaque Thrombosis and Atherogenesis.- 27. Mechanical Properties of Human Atherosclerotic Lesions.- 28. Cinemicrographic Studies of the Vasa Vasorum of Human Coronary Arteries.- 29. Atherosclerosis Regression and Arterial Repair.- 30. Adaptive Responses of the Artery Wall as Human Atherosclerosis Develops.- 31. Hemodynamic Consequences of Changes in the Artery Wall During Atherogenesis.- 32. Lipoproteins and Pathogenesis of Atherosclerosis.- 33. A Cellular Basis for the Potential Atherogenicity of Triglycer-ide-Rich Lipoproteins.- Response of Human Lesions to Direct Intervention and Risk Factor Control.- 34. Strategies for Statistical Analysis of Angiographic Data: Individual Lesions Versus Individual Patients.- 35. Quantitative Arteriography in Coronary Intervention Trials: Rationale, Study Design, and Lipid Response in the University of Washington Familial Atherosclerosis Treatment Study (FATS).- 36. Measured Coronary Lesion Change in Relation to Blood Lipid Levels in the Leiden Intervention Trial and a View of the Atherosclerotic Process.- 37. The Repetitive Plasma Exchange/Drug Trial in Familial Hypercholesterolemia: Very Early Results from Two-Year Coronary Angiograms.- 38. Histologic and Functional Basis for Ameliorating Plaques by Percutaneous Translumial Angioplasty.- 39. Angioplasty, Laser Probes and Atherectomy.- Evaluation of Lesion Status in Majo
'1. Questions About the Natural History of Human Atherosclerosis.- Cellular Contents.- 2. Arterial Endothelial Structure and Permeability as It Relates to Susceptibility to Atherogenesis.- 3. Second Messengers in Human Vascular Endothelial Cells: Regulation of Endothelial Monolayer Formation and Repair.- 4. Cytoskeletal Characterization of Smooth Muscle Cells of Human and Experimental Atherosclerotic Plaques.- 5. Phenotypic Changes in Smooth Muscle Cells of Human Atherosclerotic Plaques.- 6. Changes in the Cells of Atherosclerotic Lesions as Advanced Lesions Evolve in Coronary Arteries of Children and Young Adults.- 7. Inflammatory Components of the Human Atherosclerotic Plaque.- 8. The Role of Macrophages in Human Atherosclerosis.- 9. Recent Observations on Human Atherosclerotic Lesions, and their Possible Significance.- Tissue Organization and Architecture.- 10. Intimal Lipids and Associated Changes in Intimal Composition.- 11. Evolution of the Atherosclerotic Plaque-A Physicochemical Approach to Lipid Deposition.- 12. Modification of Collagen and Elastin in the Human Atherosclerotic Plaque.- 13. Nature and Importance of Proteoglycans in the Atherosclerotic Plaque.- 14. Biochemical and Immunological Evidence for the Presence of Lipoprotein-Antilipoprotein Immune Complexes in Human Atherosclerotic Plaques.- 15. Mechanisms of Calcification in Atherosclerosis.- 16. Characterization of Nucleating Proteolipids from Calcified and Non-Calcified Atherosclerotic Lesions.- Pathobiologic Processes.- 17. The Problems of Procedures for the Study of the Pathological Processes of Human Atherosclerosis.- 18. Problems and Progress in Understanding "Endothelial Permeability" and Mass Transport in Human Arteries.- 19. Accumulating Evidence from Human Artery Studies of What Gets Transported and What Accumulates Relative to Atherogenesis.- 20. How Hemodynamic Forces in the Human Affect the Topography and Development of Atherosclerosis.- 21. What Do We Find in Human Atherosclerosis that Provides Insight into the Hemodynamic Factors in Atherogenesis?.- 22. Cell Births and Cell Deaths in the Human Atherosclerotic Plaque as Evaluated from Human Studies.- 23. Immunocytochemical Analysis of the Cellular Composition of Atherosclerotic Lesions in the Human Aorta.- 24. An Overview of Thrombosis and Platelet Involvement in the Development of the Human Atherosclerotic Plaque.- 25. Observations Regarding the Thrombotic Process in Human Subjects.- 26. Plaque Hemorrhages, Their Genesis and Their Role in Supra-Plaque Thrombosis and Atherogenesis.- 27. Mechanical Properties of Human Atherosclerotic Lesions.- 28. Cinemicrographic Studies of the Vasa Vasorum of Human Coronary Arteries.- 29. Atherosclerosis Regression and Arterial Repair.- 30. Adaptive Responses of the Artery Wall as Human Atherosclerosis Develops.- 31. Hemodynamic Consequences of Changes in the Artery Wall During Atherogenesis.- 32. Lipoproteins and Pathogenesis of Atherosclerosis.- 33. A Cellular Basis for the Potential Atherogenicity of Triglycer-ide-Rich Lipoproteins.- Response of Human Lesions to Direct Intervention and Risk Factor Control.- 34. Strategies for Statistical Analysis of Angiographic Data: Individual Lesions Versus Individual Patients.- 35. Quantitative Arteriography in Coronary Intervention Trials: Rationale, Study Design, and Lipid Response in the University of Washington Familial Atherosclerosis Treatment Study (FATS).- 36. Measured Coronary Lesion Change in Relation to Blood Lipid Levels in the Leiden Intervention Trial and a View of the Atherosclerotic Process.- 37. The Repetitive Plasma Exchange/Drug Trial in Familial Hypercholesterolemia: Very Early Results from Two-Year Coronary Angiograms.- 38. Histologic and Functional Basis for Ameliorating Plaques by Percutaneous Translumial Angioplasty.- 39. Angioplasty, Laser Probes and Atherectomy.- Evaluation of Lesion Status in Majo
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