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This report summarizes discussions and insights from the workshop on Overcoming Barriers to Collaborative Research held March 23-24, 1998, in Irvine, California. The workshop was organized by the Government-University-Industry Research Roundtable of the National Academy of Sciences, National Academy of Engineering, and the Institute of Medicine. The purpose of the meeting was to discuss barriers to university-industry cooperation and to explore concrete approaches to overcoming them. Practitioners from universities and industry, as well as government policy makers, participated in the two-day workshop.