Drugs must be delivered to the target tissue or, better yet, the target organelles. A more specific target minimizes toxicity and side effects and maximizes therapeutic effect. This book is a comprehensive review of Organelle Targeting.
Drugs must be delivered to the target tissue or, better yet, the target organelles. A more specific target minimizes toxicity and side effects and maximizes therapeutic effect. This book is a comprehensive review of Organelle Targeting.
Dr. Lara Scheherazade Milane is the Bouvé College of Health Sciences Distinguished Educator (2021) and Assistant Teaching Professor in the Department of Pharmaceutical Sciences, Northeastern University, Boston, MA. Her research interests include mitochondrial nanomedicine and developing nanotechnology based solutions to manipulate cell communication. Dr. Milane is particularly interested in applications for treating multidrug resistant cancer and neurodegenerative diseases. Dr. Milane is also an advocate for women in science, and has 21 peer-reviewed articles, 3 white papers, and 5 book chapters. Dr. Mansoor M. Amiji is the University Distinguished Professor, Professor of Pharmaceutical Sciences, and Professor of Chemical Engineering at Northeastern University in Boston, MA. His primary areas of research interest are in the development of targeted therapeutic solutions for chronic diseases such as cancer, neurodegenerative diseases, and inflammatory diseases. Dr. Amiji has edited 10 books including Applied Physical Pharmacy (now in 3rd edition), Nanotechnology for Cancer Therapy (Taylor & Francis, 2007), Handbook of Materials for Nanomedicine (Pan Stanford Publishing, 2010), and Diagnostic and Therapeutic Applications of Exosomes in Cancer (Elsevier, 2018) along with over 70 published book chapters, and over 360 peer-reviewed articles.
Inhaltsangabe
Preface. Acknowledgments. Editors. Contributors. SECTION ONE: INTRODUCTION: ORGAN, TISSUE, AND CELLULAR LOCALIZATION. Route of Administration, Distribution, and Tissue-Specific Challenges. Nanomedicine and Drug Delivery Approaches. Escaping Immune Clearance. Passive Drug Delivery, Mechanisms of Uptake, and Intracellular Trafficking. Tumor Targeting. Localizing Therapeutics to the Brain. Pulmonary Drug Delivery. Cardiovascular Drug Delivery. Localizing Therapeutics to the Gastrointestinal System. Targeting Immune Cells and Dysfunction. SECTION TWO: OVERCOMING CELLULAR BARRIERS. Overcoming the Plasma Membrane. Overcoming the Mucus Barrier. Directing Therapies to Lysosomes. Microtubule Targeting in Cancer Treatment. Localizing Therapeutics to the Endoplasmic Reticulum. Targeting Mitochondria. Directed Therapies to Nucleic Acid and Cytoplasmic RNA. Considerations for Engineering Nanoparticles for Achieving Subcellular Organelle Targeting. Index.
Preface. Acknowledgments. Editors. Contributors. SECTION ONE: INTRODUCTION: ORGAN, TISSUE, AND CELLULAR LOCALIZATION. Route of Administration, Distribution, and Tissue-Specific Challenges. Nanomedicine and Drug Delivery Approaches. Escaping Immune Clearance. Passive Drug Delivery, Mechanisms of Uptake, and Intracellular Trafficking. Tumor Targeting. Localizing Therapeutics to the Brain. Pulmonary Drug Delivery. Cardiovascular Drug Delivery. Localizing Therapeutics to the Gastrointestinal System. Targeting Immune Cells and Dysfunction. SECTION TWO: OVERCOMING CELLULAR BARRIERS. Overcoming the Plasma Membrane. Overcoming the Mucus Barrier. Directing Therapies to Lysosomes. Microtubule Targeting in Cancer Treatment. Localizing Therapeutics to the Endoplasmic Reticulum. Targeting Mitochondria. Directed Therapies to Nucleic Acid and Cytoplasmic RNA. Considerations for Engineering Nanoparticles for Achieving Subcellular Organelle Targeting. Index.
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