Online monitoring of mammalian cell cultures - Feichter, Melanie
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Within the last years, more and more attention has been paid to the development of on-line monitoring process devices. Particularly, taking into account that the Food and Drug Administration (FDA) launched the Process Analytical Technology (PAT) guidance, which encouraged biopharmaceutical companies to ensure a pre-defined final product quality. On-line sensors are a great opportunity to gather process understanding and to enhance process development. In course of this thesis the usefulness of on-line and in-line measurements to deduct physiological key parameters and accelerate bioprocess…mehr

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Produktbeschreibung
Within the last years, more and more attention has been paid to the development of on-line monitoring process devices. Particularly, taking into account that the Food and Drug Administration (FDA) launched the Process Analytical Technology (PAT) guidance, which encouraged biopharmaceutical companies to ensure a pre-defined final product quality. On-line sensors are a great opportunity to gather process understanding and to enhance process development. In course of this thesis the usefulness of on-line and in-line measurements to deduct physiological key parameters and accelerate bioprocess development is evaluated using different human embryonic kidney (HEK) cell clones.
Autorenporträt
Born in Klagenfurt, Austria in 1989.Bachelor¿s studies of technical chemistry at Vienna University of Technology from 2008 to 2012.Master¿s studies of biotechnology und bioanalytics at Vienna University of Technology, with a focus on biochemical engineering and bioprocess technology, from 2012 to 2014.