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The monograph is devoted to the issues of embryology and histology of teeth and supporting tissues, physiology of t th eruption mechanisms and their further functioning. In addition to the systematization and generalization of scientific data on these issues, on the basis of numerous and diverse studies the author has put forward the concept of original immunological tooth-periodontal relationship during dentition, which considers many aspects of the problem being studied in normal conditions. The monograph is designed for a wide range of medical professionals as well as students of dental faculties.