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The study carried out to determine whether the alteration of inflammatory indicators was associated with obesity and/or disease conditions. Obesity was well associated with metabolic disorders as hypertension and type-2 diabetes. Adipose tissue plays an active role in endocrine function by secreting adipokines that involve inflammatory and anti-inflammatory cytokines. Within obese patients (hypertensive and/or diabetic), vitamin C has obtained anti-inflammatory effect by reducing the markers of interleukin 6 and C reactive protein, as well as, reducing blood sugar, while the Omega-3 fatty acids have obtained prophylactic properties.