Nuclear Receptors in Drug Metabolism
PAYBACK Punkte
68 °P sammeln!
Integrating the findings from several disciplines, Nuclear Receptors in Drug Metabolism enables readers to more accurately predict drug metabolism and drug-drug interactions as well as physiological outcomes. It offers a comprehensive review of the role of nuclear hormone receptors as transcriptional regulators of drug-metabolizing enzymes and transporters, helping readers understand what's known, what's in development, and what's on the horizon. In addition to drug metabolism and drug development, the book also emphasizes clinical drug use, therapeutic potentials, and pharmacogenetics.Nuclear...
Integrating the findings from several disciplines, Nuclear Receptors in Drug Metabolism enables readers to more accurately predict drug metabolism and drug-drug interactions as well as physiological outcomes. It offers a comprehensive review of the role of nuclear hormone receptors as transcriptional regulators of drug-metabolizing enzymes and transporters, helping readers understand what's known, what's in development, and what's on the horizon. In addition to drug metabolism and drug development, the book also emphasizes clinical drug use, therapeutic potentials, and pharmacogenetics.
Nuclear Receptors in Drug Metabolism features a team of expert authors. Their contributions are based not only on a thorough analysis and synthesis of the primary literature, but also their own firsthand experiences in the drug development labs. With their guidance, readers gain a deep understanding of how nuclear hormone receptors function in regulating drug-metabolizing enzymes and transporters. Among the topics covered are:
Establishing orphan nuclear receptors PXR and CAR as xenobiotic receptors
Nuclear receptor-mediated regulation of phase II conjugating enzymes and drug transporters
Structure and function of PXR and CAR
Animal models of xenobiotic nuclear receptors and their utility in drug development
Nuclear receptors and drug-drug interactions of prescription drugs and herbal medicines
Genetic variants of xenobiotic receptors and their implications in drug metabolism and pharmacogenetics
Regulation of drug-metabolizing enzymes and transporters by nuclear receptors other than PXR and CAR
Drug development scientists will find a wealth of new information and approaches to support their efforts to develop new drugs that effectively treat such diseases as cancer, coronary heart disease, diabetes, and liver diseases.
Nuclear Receptors in Drug Metabolism features a team of expert authors. Their contributions are based not only on a thorough analysis and synthesis of the primary literature, but also their own firsthand experiences in the drug development labs. With their guidance, readers gain a deep understanding of how nuclear hormone receptors function in regulating drug-metabolizing enzymes and transporters. Among the topics covered are:
Establishing orphan nuclear receptors PXR and CAR as xenobiotic receptors
Nuclear receptor-mediated regulation of phase II conjugating enzymes and drug transporters
Structure and function of PXR and CAR
Animal models of xenobiotic nuclear receptors and their utility in drug development
Nuclear receptors and drug-drug interactions of prescription drugs and herbal medicines
Genetic variants of xenobiotic receptors and their implications in drug metabolism and pharmacogenetics
Regulation of drug-metabolizing enzymes and transporters by nuclear receptors other than PXR and CAR
Drug development scientists will find a wealth of new information and approaches to support their efforts to develop new drugs that effectively treat such diseases as cancer, coronary heart disease, diabetes, and liver diseases.
Andere Kunden interessierten sich für
