Bhavya Rastogi, Upendra Nagaich, D. A. Jain

Non-Ionic Surfactant Vesicles for Ophthalmic Drug Delivery

Ocular Drug Delivery System

• Broschiertes Buch

Produktbeschreibung

Niosomes was developed and characterized for ocular drug delivery of diclofenac potassium. The present research study is a promising approach to improve corneal penetration and bio availability characteristics. Formulation also found to ensure a good entrapment efficiency and ocular bio availability of drug in-vivo. Niosome containing diclofenac potassium were prepared using surfactant and cholesterol in different ratio by Lipid film hydration technique. Niosomes were characterized For Entrapment efficiency, Particle size analysis, In-vitro drug release and In-vivo studies. Formulation with low cholesterol content which shown 82.1% Entrapment efficiency, 70.01% sustained release over a period of 10 h followed a non-fickian profile with zero order release profile. Scanning electron micrograph indicated that niosomes have a discrete spherical structure without aggregation. In-vivo study showed an availability of drug in aqueous humor for an extended time period even up to 8 hour and it showed a correlation with the release profile in-vitro. Niosome are considered the best as it showed good and high Entrapment efficiency and Vitro release with better bio availability.

Produktdetails

• Verlag: LAP Lambert Academic Publishing
• Seitenzahl: 96
• Erscheinungstermin: 6. Juni 2013
• Englisch
• Abmessung: 220mm x 150mm x 6mm
• Gewicht: 161g
• ISBN-13: 9783846589571
• ISBN-10: 3846589578
• Artikelnr.: 38518306

Autorenporträt

Mr. Bhavya Rastogi Currently associated with Sun Institute of Pharmaceutical Education & Research, M.P., as Assistant Professor- Pharmaceutics and Academic In-charge. He is actively Pursuing Research leading to Ph.D. He is LOC member of various reputed Scientific Conferences.He is also currently associated as Advisory Board Member with JAPTR.