NO modulation and potential antiarthritic effect of rolipram - Thabet, Romany;Amnah Farhan, Albaker;Rawan Deham L., Aledeilah
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Rolipram is a phosphodiesterase-4 (PDE 4) inhibitor. It is being researched as a possible alternative to current antidepressants (Washtel, 1983; Bobon et al., 1988). Recent studies show that rolipram may have antipsychotic effects (Maxwell et al.,2004; Kanes et al., 2006).There is a conflicting data about the role of nitric oxide (NO) in arthritic diseases. In the present work, we examined whether the suppression of NO production by L- NG - monomethyl arginine (L-NMMA), a non-selective NOS inhibitor or addition of exogenous NO by administration of sodium nitroprusside (SNP) can modify the effects of rolipram in adjuvant arthritic rats.…mehr

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Produktbeschreibung
Rolipram is a phosphodiesterase-4 (PDE 4) inhibitor. It is being researched as a possible alternative to current antidepressants (Washtel, 1983; Bobon et al., 1988). Recent studies show that rolipram may have antipsychotic effects (Maxwell et al.,2004; Kanes et al., 2006).There is a conflicting data about the role of nitric oxide (NO) in arthritic diseases. In the present work, we examined whether the suppression of NO production by L- NG - monomethyl arginine (L-NMMA), a non-selective NOS inhibitor or addition of exogenous NO by administration of sodium nitroprusside (SNP) can modify the effects of rolipram in adjuvant arthritic rats.
Autorenporträt
Dr.Romany Helmy Thabet, Assistant Professor of pharmacology, Faculty of Medicine, Northern Borders University, Saudi Arabia. So interested in immunopharmacology and pharmacogenomics research. My Latest Publications is titled''Genetic variants in 6-mercaptopurine pathway as potential factors of hematological toxicity in acute lymphoblastic leukemia