Next Generation Sequencing in Cancer Research

Volume 1: Decoding the Cancer Genome
Herausgegeben:Wu, Wei; Choudhry, Hani

• Broschiertes Buch

Produktbeschreibung

This volume provides an interdisciplinary perspective of applying Next Generation Sequencing (NGS) technology to cancer research. It aims to systematically introduce the concept of NGS, a variety of NGS platforms and their practical implications in cancer biology.This unique and comprehensive text will integrate the unprecedented NGS technology into various cancer research projects as opposed to most books which offer a detailed description of the technology. This volume will present true experimental results with concrete data processing pipelines, discuss the bottleneck of each platform for real project in cancer research. In additional, single cancer cell sequencing as the proof of concept will be introduced in this book, along with cutting-edge information provided will help the intended audience to develop a comprehensive understanding of the NGS technology and practical whole genome sequencing data analysis and rapidly translate into their own research, specifically in the field of cancer biology.

Produktdetails

• Verlag: Springer / Springer New York / Springer, Berlin
• Artikelnr. des Verlages: 978-1-4899-8808-9
• Softcover reprint of the original 1st ed. 2013
• Seitenzahl: 396
• Erscheinungstermin: 25. August 2015
• Englisch
• Abmessung: 235mm x 155mm x 22mm
• Gewicht: 605g
• ISBN-13: 9781489988089
• ISBN-10: 1489988084
• Artikelnr.: 43708054

Autorenporträt

Wei Wu, M.D., Ph.D. is a Research Associate for the Department of Bio Science at the University of Calgary, specializing in the cancer genome and systems biology. He has edited two volumes with Springer. In addition, he's a member of various editorial board for journals including the International Journal of Biomedical Sciences, International Journal of Molecular Medicine and Advances in Sciences and the Research Journal of Biological Sciences. Hani Choudhry, D.Phil is a member of the Genomics Research Group at the Wellcome Trust Centre for Human Genetics at Oxford University. His expertise is in high throughput next generation sequencing.

Inhaltsangabe

1. The evolution of high-throughput sequencing technologies: from Sanger to single molecule sequencing.....Chee-Seng Ku, Yudi Pawitan, Mengchu Wu, Dimitrios H. Roukos, David N. Cooper

2. Next generation sequencing in cancer epigenomics and potential clinical applications....Hong Kiat Ng, Dimitrios H. Roukos, Barry Iacopetta, Chee-Seng Ku

3. Next Generation Sequencing for Cancer Genomics.....Aarti N Desai and Abhay Jere

4. Genomic Landscape of Cancer Metastasis....Arvind Kumar Singla, Chandini Thirukkumaran and Wei Wu

5. Mapping the HIF transcription factor in cancer by ChIP-seq technology.....Johannes Schödel and David R. Mole

6. Application of next-generation sequencing to analysis of TGFbeta/SMAD4 targets in ovarian cancer.....Russell Bonneville, Kenneth Nephew, and Victor X. Jin

7. Targeted Sequencing Strategies in Cancer Research.....HoJoon Lee, Billy T. Lau and Hanlee P. Ji

8. Comprehensive genomic alterations in common cancer cell lines revealed by exome-sequencing.....Han Chang, Donald G. Jackson, Paul S. Kayne, Petra B. Ross-Macdonald, Rolf-Peter Ryseck, and Nathan O. Siemers

9. Application of next generation sequencing in RNA biomarker discovery in cancer research.....Stephen P. Fink, and Kishore Guda

10. Understanding the role of long non-coding RNAs in the cancer genome.....Wei Wu and Jennifer A. Chan

11. Identification of piRNAs in HeLa cells by massive parallel sequencing.....Yilu Lu and Yongxin Ma

12. microRNA expression in breast cancer revealed by deep sequencing technology.....Thalia A. Farazi, Carl S. Leonhardt, and Thomas Tuschl

13. RNA-seq in prostate cancer research.....ShanCheng Ren, Min Qu, Yinghao Sun

14. Next-generation sequencing for high-throughput RNA interference screens.....Toby M. Ward, Anna-Maria Jegg, and Elizabeth Iorns

15. Assessment of Mapping and SNP-detection Algorithms for Next Generation Sequencing Data for Cancer Genomics.....Weixin Wang, Feng Xu, Junwen Wang

16. Applications of very low coverage sequencing in cancer genomics copy number, virus detection and survival.....Henry M Wood

17. Tumor phylogenetics in the NGS era: Strategies, challenges and future prospects.....Ayshwarya Subramanian, Stanley Shackney and Russell Schwartz

18. Impact and challenges in assessing tumor purity by next-generation sequencing.....Xiaoping Su, Gabriel G. Malouf, and Francisco J. Esteva