New Applications of NMR in Drug Discovery and Development

Herausgeber: Garrido, Leoncio; Beckmann, Nicolau

• Gebundenes Buch

Produktbeschreibung

This book presents a review of recent developments in NMR applications in pharmaceutical research. Consideration is given to consolidated and emerging techniques and methods, many of which are not yet widely applied but are likely to provide new opportunities for drug design. The first part of the book is dedicated to the description of NMR as a tool for the analysis of chemicals and their interactions with targets. The next seven chapters describe NMR approaches to investigate in vivo models of interest in drug discovery and development, with the attention focused on anatomy, function, metabolism and molecular-cellular aspects. Finally, consideration is given to the application of in vivo NMR to the identification and characterization of biomarkers with the aim of monitoring the outcome of therapeutic intervention in selected human diseases, including the study of drug metabolism and toxicity. Aimed at NMR spectroscopists, pharmacologists, imaging researchers and pharmaceutical scientists, this title is invaluable at putting NMR in context within its role in drug discovery and development. This resource is essential reading for those both new and already active in these areas.

Produktdetails

• Verlag: RSC Publishing
• Seitenzahl: 565
• Erscheinungstermin: 24. Juli 2013
• Englisch
• Abmessung: 241mm x 161mm x 40mm
• Gewicht: 1009g
• ISBN-13: 9781849734448
• ISBN-10: 1849734445
• Artikelnr.: 36935593

Inhaltsangabe

Introduction
Part I. Small Molecules, Proteins, Cellular Systems: New Applications of High Resolution NMR in Drug Discovery and Development
Solid-state NMR in Drug Discovery and Development
High-Resolution NMR-based Metabolic Profiling in Drug Discovery and Development
In-Cell NMR Spectroscopy to Study Protein-Drug Interactions
Part II. The Whole Organism In Vivo: Increased Sensitivity Using Cryogenic Radiofrequency Coils: Application to In Vivo Phenotyping of Mice
Recent Developments of Contrast Agents, CEST and Low Fields
Pharmacological fMRI in Drug Discovery and Development
In Vivo Proton MR Spectroscopy: Animal and Human Applications at High Fields
Hyperpolarization: Concepts, Techniques and Applications
Combined PET/MRI for Improving Quantitative Imaging
Magnetic Resonance-Based Cell Imaging Using Contrast Media and Reporter Genes
Part III. Translational drug discovery: From Biological Models to the Clinics
Translational Magnetic Resonance Imaging and Spectroscopy: Opportunities and Challenges
In Vivo MRI/S for the Safety Evaluation of Pharmaceuticals
Applications of MRI and MRS in Cartilage Therapeutics and Tissue Engineering
Applications of Magnetic Resonance Spectroscopy to Psychiatric Disorders
Structural Magnetic Resonance Imaging Biomarkers in Neurodegenerative Disease
Magnetic Resonance Imaging in Respiratory Diseases: From Diagnosis to Pharmaceutical Research and Development
Cardiovascular Magnetic Resonance
Magnetic Resonance Imaging Techniques in Cancer
Subject Index