Neurocritical Care Pharmacotherapy: A Clinican's Guide is a practical, succinct but comprehensive pharmacy handbook provides up-to-date clinical guidance on the effective selection, prescription, and usage of neurocritical care drugs for patients with acute neurologic illnesses. The treatment of the critically ill neurologic patient is often difficult, specialized, and includes drugs infrequently used in other intensive care units such as antiepileptic drugs, osmotic agents or acute immunotherapy such as intravenous immunoglobulin and plasma exchange.
Neurocritical Care Pharmacotherapy: A Clinican's Guide is a practical, succinct but comprehensive pharmacy handbook provides up-to-date clinical guidance on the effective selection, prescription, and usage of neurocritical care drugs for patients with acute neurologic illnesses. The treatment of the critically ill neurologic patient is often difficult, specialized, and includes drugs infrequently used in other intensive care units such as antiepileptic drugs, osmotic agents or acute immunotherapy such as intravenous immunoglobulin and plasma exchange.
Eelco FM Wijdicks is Professor of Neurology, Mayo Clinic College of Medicine, Chair of the Division of Critical Care Neurology, and Consultant, Neurological Neurosurgical Intensive Care Unit, Saint Marys Hospital, Mayo Clinic Sarah Clark is Assistant Professor of Pharmacy, College of Medicine, Neurosciences Clinical Pharmacist ,Senior Manager Pharmacy - Clinical Practice, Saint Marys Hospital Mayo Clinic, Rochester, Minnesota
Inhaltsangabe
Preface Chapter 1: Drug Delivery, Monitoring and Interactions Bioavailability of a Drug Drug Administration Routes Drug Interactions Drug Errors Pharmacogenomics Neuropharmacology and Critical Care Pharmacology Chapter 2: Analgosedation and Neuromuscular Blockers Deciding on Sedation Sedative Drugs Analgesics Neuromuscular Blockers Neuromuscular Blockers in ICU Practice Neuromuscular Blockers Reversal Chapter 3: Agitation and Delirium Causes of delirium Clinical Features of Delirium Pharmacologic Treatment of Agitation Neuroleptics Benzodiazepines Preventive Drugs Chapter 4: Pain Management Grading Pain Types of Pain in the Neurosciences ICU Indications for Pain Management Drugs for pain Non-steroidal Anti-Inflammatory Agents Patient-controlled Analgesia Chapter 5: Osmotic Therapy The Constants of Brain Volume Hyperosmolar Fluids Osmotic Agents in Clinical Practice Chapter 6: Antiepileptic drugs Seizures in the ICU Treatment Protocols Antiepileptic Drugs Used in ICU Practice Interactions and Adjustments Chapter 7: Anticoagulation and Reversal Drugs Anticoagulation and Stroke Heparin and Warfarin Factor Xa Inhibitors Thrombin Inhibitors Hemorrhage from Anticoagulants Current Recommendations on Reversal Agents Chapter 8: Antifibrinolytics and Thrombolytics Basic Mechanisms and Targets Antifibrinolytics Fibrinolytics Thrombolytics Post-alteplase Care Chapter 9: Antiplatelet Agents Clinical Trials on Antiplatelet Agents in Stroke Current Indications for Antiplatelet Agents Antiplatelet Agents Testing Platelet Function Antiplatelet Resistance Discontinuation Antiplatelet Agents before Procedure Clinical Urgency While on Antiplatelets Chapter 10: Immunosuppression and Immunotherapy Corticosteroids Plasma Exchange Intravenous Immunoglobulin Check Point Inhibitor Immunotherapy Other Therapeutic Targets in Autoimmune Neurology Chapter 11: Antimicrobial Therapy for CNS infections Bacterial Meningitis Viral, Fungal, and Parasitic Infections The Pharmacology of Antibiotics Antivirals Antifungals Chapter 12: Vasopressors and Inotropes Mechanisms of Action in Vasopressors and Inotropes Vasopressors Inotropes Use in Clinical Practice Chapter 13: Antihypertensives and Antiarrhythmics Definition of Hypertension and Blood Pressure Goals Best Practice of Antihypertensives Control of Blood Pressure after Urgent Control Antiarrhythmic Drugs Chapter 14: Fluid Therapy Regulation of Fluid Status General Principles of Fluid Management Type of Fluids Fluid Administration Fluid Management Principles in the NICU Acute Fluid Resuscitation Chapter 15: Drugs to Correct Electrolyte and Acid Base Disorders Common Electrolyte Replacements Disorders of Sodium and Water homeostasis Drugs to manage Sodium Disorders Chapter 16: Antidotes with Overdose First Treatment Considerations Toxins and Major Laboratory Abnormalities Neurology of Overdose Commonly Used Agents for Detoxification Major Toxidromes Toxic Dysautonomias Chapter 17: Drugs for Prevention of Complications Prevention of Deep Venous Thrombosis Prevention of Hyperglycemia Prevention of Stress Ulcers Prevention of Infections Prevention of Cerebral vasospasm Chapter 18: Withdrawal Syndromes and Treatment Alcohol Withdrawal Syndrome Opioid Withdrawal Stimulant Withdrawal Baclofen Withdrawal Nicotine Withdrawal Chapter 19: Treatment of Brain Injury-associated Symptoms and Signs Control of Specific Headaches Control of Nausea and Vomiting Control of Hiccups Control of Secretions Control of Constipation and Dysmotility Control of Fever and Shivering Control of Rhabdomyolysis Chapter 20: Drugs used in Neurorehabilitation Neurostimulants Drugs for post- stroke depression Drugs for spasticity Index
Preface Chapter 1: Drug Delivery, Monitoring and Interactions Bioavailability of a Drug Drug Administration Routes Drug Interactions Drug Errors Pharmacogenomics Neuropharmacology and Critical Care Pharmacology Chapter 2: Analgosedation and Neuromuscular Blockers Deciding on Sedation Sedative Drugs Analgesics Neuromuscular Blockers Neuromuscular Blockers in ICU Practice Neuromuscular Blockers Reversal Chapter 3: Agitation and Delirium Causes of delirium Clinical Features of Delirium Pharmacologic Treatment of Agitation Neuroleptics Benzodiazepines Preventive Drugs Chapter 4: Pain Management Grading Pain Types of Pain in the Neurosciences ICU Indications for Pain Management Drugs for pain Non-steroidal Anti-Inflammatory Agents Patient-controlled Analgesia Chapter 5: Osmotic Therapy The Constants of Brain Volume Hyperosmolar Fluids Osmotic Agents in Clinical Practice Chapter 6: Antiepileptic drugs Seizures in the ICU Treatment Protocols Antiepileptic Drugs Used in ICU Practice Interactions and Adjustments Chapter 7: Anticoagulation and Reversal Drugs Anticoagulation and Stroke Heparin and Warfarin Factor Xa Inhibitors Thrombin Inhibitors Hemorrhage from Anticoagulants Current Recommendations on Reversal Agents Chapter 8: Antifibrinolytics and Thrombolytics Basic Mechanisms and Targets Antifibrinolytics Fibrinolytics Thrombolytics Post-alteplase Care Chapter 9: Antiplatelet Agents Clinical Trials on Antiplatelet Agents in Stroke Current Indications for Antiplatelet Agents Antiplatelet Agents Testing Platelet Function Antiplatelet Resistance Discontinuation Antiplatelet Agents before Procedure Clinical Urgency While on Antiplatelets Chapter 10: Immunosuppression and Immunotherapy Corticosteroids Plasma Exchange Intravenous Immunoglobulin Check Point Inhibitor Immunotherapy Other Therapeutic Targets in Autoimmune Neurology Chapter 11: Antimicrobial Therapy for CNS infections Bacterial Meningitis Viral, Fungal, and Parasitic Infections The Pharmacology of Antibiotics Antivirals Antifungals Chapter 12: Vasopressors and Inotropes Mechanisms of Action in Vasopressors and Inotropes Vasopressors Inotropes Use in Clinical Practice Chapter 13: Antihypertensives and Antiarrhythmics Definition of Hypertension and Blood Pressure Goals Best Practice of Antihypertensives Control of Blood Pressure after Urgent Control Antiarrhythmic Drugs Chapter 14: Fluid Therapy Regulation of Fluid Status General Principles of Fluid Management Type of Fluids Fluid Administration Fluid Management Principles in the NICU Acute Fluid Resuscitation Chapter 15: Drugs to Correct Electrolyte and Acid Base Disorders Common Electrolyte Replacements Disorders of Sodium and Water homeostasis Drugs to manage Sodium Disorders Chapter 16: Antidotes with Overdose First Treatment Considerations Toxins and Major Laboratory Abnormalities Neurology of Overdose Commonly Used Agents for Detoxification Major Toxidromes Toxic Dysautonomias Chapter 17: Drugs for Prevention of Complications Prevention of Deep Venous Thrombosis Prevention of Hyperglycemia Prevention of Stress Ulcers Prevention of Infections Prevention of Cerebral vasospasm Chapter 18: Withdrawal Syndromes and Treatment Alcohol Withdrawal Syndrome Opioid Withdrawal Stimulant Withdrawal Baclofen Withdrawal Nicotine Withdrawal Chapter 19: Treatment of Brain Injury-associated Symptoms and Signs Control of Specific Headaches Control of Nausea and Vomiting Control of Hiccups Control of Secretions Control of Constipation and Dysmotility Control of Fever and Shivering Control of Rhabdomyolysis Chapter 20: Drugs used in Neurorehabilitation Neurostimulants Drugs for post- stroke depression Drugs for spasticity Index
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