Charlotte Auerbach

Mutation research

Problems, results and perspectives

• Broschiertes Buch

Produktbeschreibung

This book is intended for the senior undergraduate (Honours student) in genetics, and for the postgraduate who wants a survey of the whole field or information on a special area within it. In order to cater for readers with such different requirements, I have made the list of references unusually large for a textbook. It includes classical papers as well as very recent ones (to the end of 1974); reviews as well as specialized articles; elementary expositions from Scientific American as well as highly technical papers from journals on genetics and molecular biology. In areas of active research, I have given preference to the latest references, which will lead the reader to earlier ones. In addition to the references at the end of each chapter, a bibliography at the end of the book lists relevant books and general reviews. Apart from the first chapter, the book is not written as a history of mutation research; but throughout I have tried to emphasize the continuity of the problems,concepts and ideas. The reader will find many examples of this. Muller's once famous and then almost forgotten classification of genes by their action has now been given biochemical reality by studies of gene action in vitro. The problem of whether mutations can arise in non-replicating genomes is one of the oldest in mutation research; yet an unequivocal solution was obtained only recently with bacteriophage.

Produktdetails

• Verlag: Springer / Springer US / Springer, Berlin
• Artikelnr. des Verlages: 978-0-412-11280-5
• Softcover reprint of the original 1st ed. 1976
• Seitenzahl: 536
• Erscheinungstermin: 1. Januar 1976
• Englisch
• Abmessung: 235mm x 155mm x 29mm
• Gewicht: 803g
• ISBN-13: 9780412112805
• ISBN-10: 0412112809
• Artikelnr.: 41326842

Inhaltsangabe

1 The history of mutation research.- 2 Classification of mutational changes at the chromosomal level.- 3 Classification of gene mutations.- 4 Reverse mutations. Suppressors.- 5 The classical X-ray work. I: Mutations. The target theory.- 6 The classical X-ray work II: Chromosome breaks and rearrangements. Do X-rays produce true gene mutations?.- 7 Direct and indirect action of X-rays. Radio-isotopes. Radiation-sterilized food.- 8 Repair of X-ray damage I: Repair of chromosome breaks.- 9 Repair of X-ray damage II: Repair of mutagenic lesions. Molecular action of X-rays. Sensitivity differences.- 10 Mutagenesis by ultraviolet and visible light I: Early work on macro-organisms.- 11 Mutagenesis by ultraviolet and visible light II: Methods of mutation research on microorganisms and mammalian cell cultures.- 12 Mutagenesis by ultraviolet and visible light II: Early work on micro-organisms.- 13 The molecular action of ultraviolet and visible light I: Photoproducts. Photorepair.- 14 The molecular action of ultraviolet and visible light II: Dark repair. Mechanisms of mutation induction.- 15 Chemical mutagens: alkylating agents. I: Genetical effects.- 16 Chemical mutagens: alkylating agents. II: Chemistry. Molecular analysis of mutants. Influence of cellular processes. Kinetics.- 17 Chemical mutagens: purines; base analogues; acridines; hydroxylamine; hydrazine; bisulphite. Reversions analysis.- 18 Nitrous acid. Other chemical mutagens.- 19 The relation between induced crossovers, rearrangements and mutations. The origin of complete (non-mosaic) mutations.- 20 Mutagen specificity.- 21 Spontaneous mutations.- 22 Instabilities.- 23 Applied mutation research.- Author Index.