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The book presents a set of novel, efficient and systematic concurrent multiscale optimization methods by considering the distribution of the material in macro-scale and the unit-cell configuration design in micro-scale simultaneously. Different from the traditional optimization method that is performed in a single scale, the proposed methods could generate a great deal of improvements in structural performance through the multiscale structure-material concurrent optimum design. The proposed theory and methods are related to statics, dynamics, thermoelastics and the coupling of different physical fields. Therefore, it provides a comprehensive designing scheme when multiple factors are taken into account. For example, the designing scheme can have a great significance on enhancing the structural performances under coupled multi-physical fields, such as load bearing capacity, vibration resistance ability, and safety under thermal stress and so on. Several numerical examples are highlighted in this unique volume based on practical engineering applications. The examples collectively demonstrate drastically improved designs featuring excellent unit-cell configuration and highly regular macroscale material distribution in a variety of industrial applications.