Designed to help busy clinicians understand and implement the most current, evidence-based diagnostic and treatment approaches, Multiple Sclerosis: Clinician's Guide to Diagnosis and Treatment considers the disease in its totality, epidemiology, classification, patterns and pathophysiology, complications and comorbidities, and management and therapy.
Designed to help busy clinicians understand and implement the most current, evidence-based diagnostic and treatment approaches, Multiple Sclerosis: Clinician's Guide to Diagnosis and Treatment considers the disease in its totality, epidemiology, classification, patterns and pathophysiology, complications and comorbidities, and management and therapy.
Director, Multiple Sclerosis Treatment and Research Center, Minneapolis Clinic of Neurology, Clinical Profesor of Neurology, University of Minnesota School of Medicine, Minneapolis, Minnesota
Inhaltsangabe
Introduction 1. A Brief History of Multiple Sclerosis a.Experimental Autoimmune Encephalomyelitis 2. Factors Involved in Causing Multiple Sclerosis a.Epidemiology b.Causes of MS c.Immunology 3. The Patterns and Pathophysiology of Multiple Sclerosis a.Patterns of MS b.Pathophysiology of MS 4. Imaging of the Central Nervous System in Multiple Sclerosis a.Standard X-Ray Imaging of the Skull and Spinal Columns b.Computed Tomography (CT) Imaging of the CNS c.Magnetic Resonance Imaging 5. Making a Diagnosis of Multiple Sclerosis a.Patterns of Disease Presentation b.Demographics c.Genetics of MS d.Initial Clinical Symptoms in Persons with Relapsing-Remitting MS e.Initial Clinical Symptoms of Primary-Progressive MS f.Presenting Signs in MS g.Magnetic Resonance Imaging h.Evoked Responses i.Cerebrospinal Fluid Analysis j.Ruling Out "MS Look-alikes" k.Algorithms for the Diagnosis of MS l.Imparting a Diagnosis of MS 6. Complications and Comorbidities of Multiple Sclerosis a.Loss of Bone Density (Osteopenia or Osteoporosis) b.Sleep Apnea and Other Altered Sleep Patterns c.Mood Disturbances d.Urinary Tract and Other Infections e.Sexual Dysfunction f.Skin Lesions g.Joint Dysfunction h.Obesity 7. Relapses of Multiple Sclerosis and Their Treatment a.What Constitutes a Relapse? b.Conventional Relapse Treatments c.Unconventional Relapse Treatments d.Relapse Prevention 8. Long-Term Disease-Modifying Therapies a.Issues with Long-Term Immune-Modulating Therapies b.Beta-Interferons c.Glatiramer Acetate d.Second-Line Disease-Modifying Therapies e.When Should Long-Term Immune-Modulating Therapy Be Stopped? f.Future Therapies 9. Management of Multiple Sclerosis Symptoms a. Fatigue b.Depression c.Pain d.Spasticity e.Sexual Dysfunction f.Conclusion 10. Complementary Therapies for Multiple Sclerosis a.Physical Therapy b.Exercise Physiologists c.Occupational Therapy d.Psychiatrists, Counselors, and Psychologists e.Neuropsychologists f.Orthotists g.Neuro-Ophthalmologists h.Urologists i.Social Workers j.Diet, Nutrition, and Food Supplements 11. Gender Issues and Special Multiple Sclerosis Populations a.Women b. Men c.Children of Parents with MS d.Pediatric MS 12. Resources a.Web Sites b.Patient Advocacy Organizations c.Sites for Disease-Modifying Therapies d.Site for MR Imaging Protocol for MS e.Patient Books and Materials Index
Introduction 1. A Brief History of Multiple Sclerosis a.Experimental Autoimmune Encephalomyelitis 2. Factors Involved in Causing Multiple Sclerosis a.Epidemiology b.Causes of MS c.Immunology 3. The Patterns and Pathophysiology of Multiple Sclerosis a.Patterns of MS b.Pathophysiology of MS 4. Imaging of the Central Nervous System in Multiple Sclerosis a.Standard X-Ray Imaging of the Skull and Spinal Columns b.Computed Tomography (CT) Imaging of the CNS c.Magnetic Resonance Imaging 5. Making a Diagnosis of Multiple Sclerosis a.Patterns of Disease Presentation b.Demographics c.Genetics of MS d.Initial Clinical Symptoms in Persons with Relapsing-Remitting MS e.Initial Clinical Symptoms of Primary-Progressive MS f.Presenting Signs in MS g.Magnetic Resonance Imaging h.Evoked Responses i.Cerebrospinal Fluid Analysis j.Ruling Out "MS Look-alikes" k.Algorithms for the Diagnosis of MS l.Imparting a Diagnosis of MS 6. Complications and Comorbidities of Multiple Sclerosis a.Loss of Bone Density (Osteopenia or Osteoporosis) b.Sleep Apnea and Other Altered Sleep Patterns c.Mood Disturbances d.Urinary Tract and Other Infections e.Sexual Dysfunction f.Skin Lesions g.Joint Dysfunction h.Obesity 7. Relapses of Multiple Sclerosis and Their Treatment a.What Constitutes a Relapse? b.Conventional Relapse Treatments c.Unconventional Relapse Treatments d.Relapse Prevention 8. Long-Term Disease-Modifying Therapies a.Issues with Long-Term Immune-Modulating Therapies b.Beta-Interferons c.Glatiramer Acetate d.Second-Line Disease-Modifying Therapies e.When Should Long-Term Immune-Modulating Therapy Be Stopped? f.Future Therapies 9. Management of Multiple Sclerosis Symptoms a. Fatigue b.Depression c.Pain d.Spasticity e.Sexual Dysfunction f.Conclusion 10. Complementary Therapies for Multiple Sclerosis a.Physical Therapy b.Exercise Physiologists c.Occupational Therapy d.Psychiatrists, Counselors, and Psychologists e.Neuropsychologists f.Orthotists g.Neuro-Ophthalmologists h.Urologists i.Social Workers j.Diet, Nutrition, and Food Supplements 11. Gender Issues and Special Multiple Sclerosis Populations a.Women b. Men c.Children of Parents with MS d.Pediatric MS 12. Resources a.Web Sites b.Patient Advocacy Organizations c.Sites for Disease-Modifying Therapies d.Site for MR Imaging Protocol for MS e.Patient Books and Materials Index
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