Multi Walled Carbon Nanotubes Bearing Artesunate for Cerebral Malaria - Sahu Gulbake, Anamika;Jain, Aviral;Gulbake, Arvind
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Malaria is one of the major health problem caused by a protozoan belonging to the genus plasmodium. Cerebral malaria comprises the clinical reflections of plasmodium falciparum malaria which causes mutations in mental status and sometimes, coma. It is an intense disease of the brain, causing ring-like lesions in the brain, accompanied by fever. The patient should be treated as early as possible, as cerebral malaria gets fatal within 24-72 hours. Thus, f-MWCNTS provide better platform for protecting bioactive from degradation in endosomal milieu and hence a better intracellular bioactive…mehr

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Produktbeschreibung
Malaria is one of the major health problem caused by a protozoan belonging to the genus plasmodium. Cerebral malaria comprises the clinical reflections of plasmodium falciparum malaria which causes mutations in mental status and sometimes, coma. It is an intense disease of the brain, causing ring-like lesions in the brain, accompanied by fever. The patient should be treated as early as possible, as cerebral malaria gets fatal within 24-72 hours. Thus, f-MWCNTS provide better platform for protecting bioactive from degradation in endosomal milieu and hence a better intracellular bioactive efficacy could be obtained. Functionalization of MWCNTs improve their efficacy, due to their increased internalization capacity or for efficient intra-cellular uptake, vis-a-vis increase their dispersibility. Artesunate could be successfully loaded in the purified as well as various functionalized MWCNTs. Mannose conjugated MWCNTs shows highest entrapment efficiency and sustained release. Mannosylation improved the dispersibility of MWCNTs in aqueous solvents and these can be developed for delivery of different bioactive(s) as well as active ligand (mannose)-based targeting to brain tissue.
Autorenporträt
La Sra. Anamika trabaja actualmente como profesora asistente en el Sarojini College of Pharmacy, Kolhapur. Completó su postgrado en la Universidad RGPV, Bhopal en el año 2013. Ha publicado 8 publicaciones en revistas internacionales (Scopus) y también ha publicado capítulos de libros en libros nacionales e internacionales.