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DENV is the most important factors transmitted by mosquitoes worldwide causing viral disease, almost 100 million cases of dangerous DENV each year, resulting in severe and life-threatening. However, we have not completed a comprehensive outlook of all miRNAs expression regulation target genes through virus-human interactions in patients of DENV. A few human miRNAs might show antiviral miRNAs. When some delusive antiviral miRNAs were blocked by locked nucleic acid-modified antisense oligoribonucleotides, the hosts miss carriage to suppress viral replication. Schul et al. Found that higher levels of viremia were linked with increased DENV intensity and proposed that lowering viremia may reduce morbidity and the risk of dengue hemorrhagic fever or dengue shock syndrome. Infected mice by dengue showed increased TNF-a, IFN-g and IL-6 levels, which were recognized as triggers for DENV