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Over the past 30 years one alarming trend is the emergence of plant species resistant to agrochemicals (e.g. insecticides, herbicides, fungicides). Considering the fact that these pesticides are crucial to human health and to food, feed and fiber production, impressive research was carried out during the last decade to understand the mechanisms of resistance development. This volume reviews the latest results and examines the implications of these findings for delaying or avoiding resistance in plants to agrochemicals.