Rainer Fischer / Stefan Schillberg (Hgg.)

Molecular Farming

Plant-made Pharmaceuticals and Technical Proteins
Herausgegeben:Fischer, Rainer; Schillberg, Stefan

• Gebundenes Buch

Produktbeschreibung

Authors from academia and industry provide a fascinating overview of current production technologies and possible future applications. Topics include chloroplast-derived antibodies, biopharmaceuticals and edible vaccines, antibodies in plants and plant cell suspension cultures, spider silk proteins, and glycosylation of plant produced proteins. For biotechnologists, gene technologists, molecular biologists and protein biochemists at universities as well as the biotechnological and pharmaceutical industries.

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Die Produktion von Arznei- und Impfstoffen in Pflanzen ist kostengünstig, sicher und problemlos in großtechnischem Maßstab möglich.
Bisher findet die Herstellung rekombinanter Proteine, also diagnostischer und therapeutischer Wirkstoffe sowie biologischer und pharmazeutischer Werkstoffe, noch größtenteils mit Hilfe von gentechnisch veränderten Mikroben oder tierischen Zellen statt. Zukünftig wird die biologisch sichere, ökologisch verträgliche und kostengünstige Produktion von pharmazeutisch nutzbaren Proteinen in Pflanzen zwingend notwendig, zumal schon heute die konventionellen Produktionskapazitäten (Bakterien, Hefen, Säugetierzellen) für rekombinante Proteine nicht mehr ausreichend sind.
Die in Wissenschaft und Wirtschaft tätigen Autoren dieses Buches geben zunächst einen Überblick über Grundlagen und Anwendungsmöglichkeiten des "Molecular Farming", bevor sie sich im zweiten Teil mit neuesten Methoden und Produktionssystemen beschäftigen. Das Potential des "Molecular Farming" wird schließlich beispielhaft anhand der Produktion technischer Proteine (pharmazeutische und biologische Werkstoffe) und pharmazeutischer Proteine (diagnostischer und therapeutischer Wirkstoffe) dargestellt.

Produktdetails

• Verlag: Wiley-VCH
• Seitenzahl: 280
• Englisch
• Abmessung: 240mm
• Gewicht: 764g
• ISBN-13: 9783527307869
• ISBN-10: 3527307869
• Artikelnr.: 12736355

Autorenporträt

Prof. Dr. Rainer Fischer, 45, currently Department Head of the Institute for Molecular Biotechnology (RWTH Aachen, Germany, 80 employees) and Senior Executive Director of the Fraunhofer Institute for Molecular Biology and Applied Ecology (170 employees). His research covers many areas of Molecular Biotechnology including Genomics, Proteomics, Cellomics, Protein Engineering, Molecular Medicine, Immunology, Virology, Plant Biotechnology, as well as the Production and Purification of Recombinant Proteins.
Within the last 15 years Prof. Dr. Rainer Fischer published over 90 research articles in leading international journals, 35 book chapters and established a strong global academic and industrial network. He is also well known within the scientific arenas for his international scientific talks, is on the editorial board of two highly ranked scientific journals and is reviewer for more than 20 journals. He has filed over 25 different patent applications and successfully secured more than 100 million Euros in financial support. Prof. Fischer serves as reviewer for multiple national and international grant agencies (EC, NATO and NSF), he is an adviser for four international Biotech companies and an active board member for two start-up companies.

Inhaltsangabe

INTRODUCTION
PLANT PRODUCTION TECHNOLOGIES
Perennial plants as a production system for pharmaceuticals
Foreign protein expression using hairy roots and plant suspension cultures
Production of recombinant proteins in germinating seeds
Viral expression vectors
Field trials
Chloroplast derived antibodies, biopharmaceuticals and edible vaccines
sIgA production in plants
Antibodies in plants and plant cell suspension cultures
Production of spider silk proteins in plants
Glycosylation of plant produced proteins
The precautionary approach to tackle the wicked problems
Requirements and expectations of Molecular Farming from the view of big pharma
Choice of crop species and improving recombinant protein levels
Gene farming in pea under field conditions: Seed specific synthesis of a bacterial exoenzyme

Rezensionen

"Authors from academia and industry provide a fascinating overview of current production technologies and possible future applications." Bioworld

"... a valuable introduction. ... This volume, although aimed at a scientific audience, can be regarded as an early indication of a coming debate... Each chapter is concise but they all have many references ... I recommend this book." Chemistry & Industry

"... this is an excellent book on this exciting new subject." American Journal of Therapeutics

"... covers a large amount of highly detailed material in a clear and concise manner." Drug Development and Industrial Pharmacy