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The results of this study revealed that RAB11A gene expression were up regulated in the liver tissues of HCC rats (median RQ 6.8 and 6.8) when compared to normal control rat (median RQ 0.71 and 1.35) and Hesperidin treated groups (median RQ 0.85, 1.76 and 0.42) and (median RQ 12.44, 5.16, 1.12) respectively. And in serum these markers were up regulated in HCC rats (median RQ 8.7 and 8.7) when compared to normal control rat (median RQ 1.57 and 0.51) and Hesperidin treated groups (median RQ 2.41, 5.85, 0.25) and (median RQ 2.07 ,5.80, 8.42) respectively. there was significant difference among the studied groups as regards fold change (RQ) of RAB11A mRNA in serum and liver tissues (P< 0.01).