Molecular and Cellular Effects of LLLT in Diabetic Wound Healing - Houreld, Nicolette;Abrahamse, Heidi
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Wound healing is a complex procedure involving a variety of cells, cytokines and growth factors. Disregulation of this procedure leads to chronic, slow-to-heal wounds, a complication commonly found in diabetes. Diabetes results in hyperglycemia which in turn damage blood vessels and nerves, leading to delayed wound healing that often requires lower limb amputation. Low Level Laser Therapy (LLLT), commonly known as phototherapy, has emerged as an alternative treatment; it abates the inflammatory reaction and stimulates wound healing. Despite the advocacy of this treatment, there has been a…mehr

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Produktbeschreibung
Wound healing is a complex procedure involving a variety of cells, cytokines and growth factors. Disregulation of this procedure leads to chronic, slow-to-heal wounds, a complication commonly found in diabetes. Diabetes results in hyperglycemia which in turn damage blood vessels and nerves, leading to delayed wound healing that often requires lower limb amputation. Low Level Laser Therapy (LLLT), commonly known as phototherapy, has emerged as an alternative treatment; it abates the inflammatory reaction and stimulates wound healing. Despite the advocacy of this treatment, there has been a reluctance to accept it due to a lack of an understanding of the underlying mechanisms of action. The effect of wavelength, beam type, energy output, energy level, energy intensity and exposure regime remain unexplained, and no therapeutic window for dosimetry and mechanism of action has been determined at the level of individual cells types. Both clinicians and researchers will find this book helpful as it provides a basic understanding of the cellular and molecular effects of laser irradiation on diabetic wounded cells in vitro.
Autorenporträt
Nicolette Houreld completed her post-doctoral study at the Laser Research Centre, in 2009. Her research interests include the effect of laser irradiation on wound healing. She has published 17 papers, 5 conference proceedings, is a reviewer for 6 journals and is a member of the executive committee of the World Association for Laser Therapy.